Bone marrow failure syndromes — Flashcards

Flashcard 1: _____ disorders are neoplastic proliferations of mature cells of myeloid lineage

Answer: Myeloproliferative

Flashcard 2: Impaired division and enlargement of RBC precursors leads to _____, macrocytic anemia

Answer: megaloblastic

Flashcard 3: Chediak-Higashi syndrome is associated with defective _____ hemostasis

Answer: primary

Flashcard 4: What pathologic RBC is seen with bone marrow infiltration (e.g. myelofibrosis, thalassemias)?_____

Answer: Dacrocyte ("tear drop cell")

Flashcard 5: Myelodysplastic syndromes rarely may progress to _____ leukemia

Answer: acute myeloid

Flashcard 6: Which immunodeficiency is characterized by giant granules in leukocytes and platelets? _____

Answer: Chediak-Higashi syndrome

Flashcard 7: Aplastic anemia is characterized by an empty, _____ marrow on biopsy ("dry marrow tap")

Answer: fatty (characteristic)

Flashcard 8: testicular lymphoma

Answer: mets from primary lymphoma

Extra: poor; aggressiveolder men

Flashcard 9: What kinds of tissue samples can be used for karyotyping?

Answer: blood, bone marrow, amniotic fluid, placental tissue