Acute leukemias — Flashcards

Flashcard 1: The t(9;22) translocation (BCR-ABL) is also known as the _____ chromosome

Answer: Philadelphia

Flashcard 2: What pathologic RBC is associated with myelofibrosis? _____

Answer: "Tear drop" cells (dacrocyte)

Flashcard 3: Acute leukemia is defined as a neoplastic proliferation of blasts _____% in the bone marrow

Answer: > 20

Flashcard 4: _____ leukemia is associated with the t(12;21) translocation

Answer: Acute lymphoblastic

Flashcard 5: The t(15;17) translocation seen in acute promyelocytic leukemia results in disruption of the _____ receptor on chromosome 17

Answer: retinoic acid

Flashcard 6: What pathologic RBC finding is seen in bone marrow with sideroblastic anemia, lead poisoning, and myelodysplastic syndrome? _____

Answer: Ringed sideroblasts

Flashcard 7: testicular lymphoma

Answer: mets from primary lymphoma

Extra: poor; aggressiveolder men

Flashcard 8: What kinds of tissue samples can be used for karyotyping?

Answer: blood, bone marrow, amniotic fluid, placental tissue