Amyloidosis — Flashcards

Flashcard 1: What pathologic RBC is seen with bone marrow infiltration (e.g. myelofibrosis, thalassemias)?_____

Answer: Dacrocyte ("tear drop cell")

Flashcard 2: _____ stain identifies glycogen and is thus useful in identifying glycogen storage diseases

Answer: Periodic acid-Schiff (PAS)

Flashcard 3: Amyloid may be visualized as _____ under polarized light

Answer: apple-green birefringence

Flashcard 4: What type of scar is characterized by disorganized collagen organization?_____

Answer: Keloid scar

Flashcard 5: Disorders of fibrinolysis typically present with _____ fibrinogen

Answer: decreased

Flashcard 6: fat necrosis (breast)

Answer: fat necrosis and saponification following trauma (often mild or unremarkable trauma)

Extra: painless breast lump

Flashcard 7: The subtypes of fibrocystic disease of the breast are _____, _____, _____, and _____.

Answer: fibrosis

Flashcard 8: aplasia (organogenesis)

Answer: absent organ despite present primordial tissue

Flashcard 9: death

Answer: prolonged nutrient depletion and waste build-up leads to death

Extra: D

Flashcard 10: How do Duchenne's and Becker's muscular dystrophies differ genetically?

Answer: DMD is a frameshift mutation effectively deleting the gene. BMD is a partial loss of function mutation.