Free radical injury — Flashcards

Flashcard 1: Pathologic generation of free radicals arises with ionizing radiation, which hydrolyzes H2O to _____

Answer: OH-

Flashcard 2: _____ membrane damage in irreversible cell injury results in hydrolytic enzymes leaking into the cytosol

Answer: Lysosome

Flashcard 3: Mitochondrial _____ signifies irreversible cellular injury

Answer: vacuolization

Flashcard 4: Overdose of acetaminophen causes _____ necrosis

Answer: hepatic

Flashcard 5: Cellular injury is characterized by _____ activity of the Na+-K+ and Ca2+ pumps

Answer: decreased

Flashcard 6: In -thalassemia major, _____ tetramers precipitate and damage RBCs

Answer: 4

Flashcard 7: Fat necrosis of breast tissue presents as a painless _____ on physical exam

Answer: mass

Extra:   * Necrosis may be tender and painful, as well; "irregular breast mass" Watch Benign Breast Disorders [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-breast-benign-breast-disorders?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/inflammation-and-neoplasia/necrosis/acquire?ref=anki 

Flashcard 8: Niemann Pick disease may present with progressive _____

Answer: neurodegeneration

Extra:   https://onlinemeded.org/spa/metabolism?ref=anki 

Flashcard 9: Which layer of the cerebellum is most affected by global cerebral ischemia? _____

Answer: Purkinje layer

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/neurology/videos/ischemic-cerebrovascular-accidents?index=2] https://onlinemeded.org?ref=anki Atlas: 

Flashcard 10: Ionizing radiation results in the formation of double-stranded breaks in DNA and _____ which damage DNA

Answer: hydroxyl free radicals

Extra:   https://onlinemeded.org?ref=anki