Oncogenic viruses — Flashcards

Flashcard 11: Which layer of the epithelium does HPV infect? _____

Answer: Stratum basale

Extra:   Watch Human papillomavirus (Papillomaviridae) [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-viruses/videos/medical-microbiology-viruses-dna-viruses-human-papillomavirus-papillomaviridae?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch Cervical Neoplasia [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-metabolism/videos/medical-biochemistry-metabolism-carbohydrates-gluconeogenesis?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/gynecology/cervical-cancer/acquire?ref=anki 

Flashcard 12: Epstein-Barr virus (EBV) remains dormant in _____ cells, which increases risk for lymphoma, especially if immunodeficiency develops (e.g. HIV)

Answer: B

Extra:  https://onlinemeded.org/spa/hematology-oncology/leukemia/acquire?ref=anki Atlas: 

Flashcard 13: HHV-8 causes _____

Answer: Kaposi Sarcoma

Extra:  https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 14: Where is EBV latent?_____

Answer: B cells

Flashcard 15: Viruses such as EBV, HHV-8, HBV/HCV, etc are said to be _____ viruses due to them causing cancer

Answer: oncogenic

Flashcard 16: What is the cancer risk associated with HPV6?_____

Answer: Low

Flashcard 17: Which oncogenic microbe is associated with the following cancers?:_____Lymphomas (ex. Endemic Burkitt Lymphoma)Nasopharyngeal CarcinomaPrimary CNS Lymphoma (in AIDS)Posttransplant Lymphoproliferative Disease

Answer: EBV

Flashcard 18: What is the cancer risk associated with HPV31?_____

Answer: High

Flashcard 19: What are 4 characteristics of HPV itself?_____

Answer: Non-enveloped (naked), icosahedral, circular, dsDNA virus (enveloped?, shape?, circular/linear?, DNA/RNA?)

Flashcard 20: What types of HPV encode for the proteins E6 and E7?_____

Answer: High Risk (HPV 16, 18, 31, 33)