HIV-associated malignancies — Flashcards

Flashcard 1: HIV initially infects what cell type?_____

Answer: Macrophages

Flashcard 2: HIV has _____ strands of RNA in its genome

Answer: two

Flashcard 3: _____ is a regulatory protein of HIV that transcriptionally activates other viral genes.

Answer: Tat

Flashcard 4: _____ are diploid single-stranded RNA viruses

Answer: Retroviruses (ie: HIV)

Flashcard 5: progressive multifocal leukoencephalopathy (PML)

Answer:

Extra: destruction of oligodendrocytes, demyelination of CNSrapidly progressive, usually fatalrecent JC virus infection, AIDS

Flashcard 6: The _____ blot *used to be* the confirmatory test for HIV after a positive ELISA

Answer: Western

Extra:   https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 7: Which HIV gene encodes for the virion p24 (Capsid) and p17 (Matrix) core proteins? _____

Answer: gag

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 8: Which envelope protein on HIV binds the CD4 molecule and a chemokine receptor (CXCR4 or CCR5)? _____

Answer: gp120

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 9: Individuals with _____-zygous CCR5 allele mutations display a slower rate of progression of HIV infection

Answer: hetero

Extra:    https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 10: Which viral gene in HIV codes for its Reverse Transcriptase? _____

Answer: pol

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki