Hepatitis B/C — Flashcards

Flashcard 1: Hepatitis C virus displays antigenic variability of its _____ proteins

Answer: envelope

Extra:   Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 2: Developed countries purify their _____ supply, eliminating HAV infection risk (fecal-oral transmission)

Answer: water

Extra:   Watch Hepatitis A virus (PicoRNAviridae) [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-viruses/videos/medical-microbiology-viruses-rna-viruses-positive-sense-hepatitis-a-virus-picornaviridae?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 3: Which hepatitis virus shows antigenic variability of envelope proteins? _____

Answer: HCV

Extra:    https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 4: The vaccines for _____ are recombinant vaccines

Answer: Hepatitis B and HPV 6, 11, 16, 18

Extra:  https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 5: What is the first detectable antibody in HBV infection? _____

Answer: Anti-HBc IgM

Extra:   Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 6: Upon cellular entry, partially dsDNA of HBV is repaired and used for _____

Answer: transcription

Extra:  https://onlinemeded.org/spa/microbiology/hepatitis-viruses/acquire?ref=anki 

Flashcard 7: The vaccine for Hepatitis B Virus uses recombinant _____

Answer: HbsAg

Extra:  https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 8: Once the dsDNA of HBV is complete, _____ RNA polymerase transcribes mRNA from the dsDNA

Answer: host

Extra:   Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 9: HAV infection is commonly seen in _____ to endemic areas

Answer: travelers

Extra:   Watch Hepatitis A virus (PicoRNAviridae) [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-viruses/videos/medical-microbiology-viruses-rna-viruses-positive-sense-hepatitis-a-virus-picornaviridae?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 10: Does hepatitis D have an envelope? _____

Answer: Yes

Extra:   Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 11: Hepatitis D is from the _____ family

Answer: deltaviridae

Extra:   Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 12: Hepatitis E virus is acid-_____

Answer: stable

Extra:   Watch Hepatitis A virus (PicoRNAviridae) [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-viruses/videos/medical-microbiology-viruses-rna-viruses-positive-sense-hepatitis-a-virus-picornaviridae?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 13: What serologic marker must be present for HDV infection? _____

Answer: HBsAg

Extra:   Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 14: Hepatitis A virus is acid-_____

Answer: stable

Extra:   Watch Hepatitis A virus (PicoRNAviridae) [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-viruses/videos/medical-microbiology-viruses-rna-viruses-positive-sense-hepatitis-a-virus-picornaviridae?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 15: Hepatitis _____ virus cannot cause disease without hepatitis B HBsAg

Answer: D

Extra:    https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki  

Flashcard 16: Which serologic markers are detectable during the recovery period of HBV infection? _____

Answer: Anti-HBs IgG; Anti-HBc IgG

Extra:   Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki  

Flashcard 17: What is the shape of the HBV genome? _____

Answer: Circular

Extra:   Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 18: What family of viruses does HCV belong to? _____

Answer: Flaviviridae

Extra:   Watch Flaviviridae overview [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-viruses/videos/medical-microbiology-viruses-rna-viruses-positive-sense-flaviviridae-overview?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/infectious-disease?ref=anki 

Flashcard 19: Which serologic marker is detectable during the window period of HBV infection? _____

Answer: Anti-HBc IgM

Extra:   Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki  may be the only diagnostic marker for acute HBV infection during this time - see the window 

Flashcard 20: What type of virus is Hepatitis B? _____

Answer: Partially double-stranded DNA

Extra:  https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 21: Before beginning treatment for HCV - a clinical history, physical exam, and _____ are undergone

Answer: genotyping

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 22: _____ is a deltavirus that causes hepatitis

Answer: HDV

Extra:  https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 23: Which hepatitis virus lacks 3'-5' exonuclease activity? _____

Answer: HCV

Extra:   Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/hepatic-pathology?index=4] https://onlinemeded.org/spa/gastroenterology/viral-hepatitis/acquire?ref=anki 

Flashcard 24: Anti-HBc IgM is the sole marker during the _____

Answer: window period

Extra:  https://onlinemeded.org/spa/infectious-disease?ref=anki 

Flashcard 25: HBsAg indicates _____

Answer: active infection

Extra:  https://onlinemeded.org/spa/infectious-disease?ref=anki 

Flashcard 26: What serologic marker must be present for HDV infection?_____

Answer: HBsAg

Flashcard 27: Developed countries purify their _____ supply, eliminating HAV infection risk (fecal-oral transmission)

Answer: water

Flashcard 28: What type of vaccine is the HAV vaccine?_____

Answer: Inactivated/killed

Flashcard 29: Which hepatitis virus lacks 3'-5' exonuclease activity?_____

Answer: HCV

Flashcard 30: What is the mechanism for antigenic variation of envelope proteins in HCV?_____

Answer: Lack of 3'-5' exonuclease -> lack of proofreading -> antigenic variation

Flashcard 31: Which hepatitis virus shows antigenic variability of envelope proteins?_____

Answer: HCV

Flashcard 32: What is the first detectable antibody in HBV infection?_____

Answer: Anti-HBc IgM

Flashcard 33: Hepatitis _____ virus cannot cause disease without hepatitis B HBsAg

Answer: D

Flashcard 34: Which serologic marker is detectable during the window period of HBV infection?_____

Answer: Anti-HBc IgM

Flashcard 35: What type of vaccine is used for HBV? _____

Answer: Subunit (recombinant HBsAg)

Flashcard 36: _____ is a deltavirus that causes hepatitis

Answer: HDV

Flashcard 37: What type of virus is Hepatitis D? (DNA, RNA (sense), etc.)_____

Answer: Negative sense RNA

Flashcard 38: The vaccine for Hepatitis B Virus uses recombinant _____

Answer: HbsAg

Flashcard 39: Does hepatitis B have an envelope?_____

Answer: Yes

Flashcard 40: Hepatitis A virus is acid-_____

Answer: stable

Flashcard 41: What is the shape of the HBV genome?_____

Answer: Circular

Flashcard 42: What is the second marker that appears in HBV infection?_____

Answer: HBeAg

Flashcard 43: What type of virus is Hepatitis B? (DNA, RNA (sense), etc.)_____

Answer: DNA

Flashcard 44: Hepatitis D is from the _____ family

Answer: deltavirus

Flashcard 45: What type of virus is HCV? (DNA, RNA (sense), etc.)_____

Answer: Positive sense RNA

Flashcard 46: What is the first marker that appears in HBV infection?_____

Answer: HBsAg

Flashcard 47: Upon cellular entry, partially dsDNA of HBV is repaired and used for _____

Answer: transcription

Flashcard 48: What family of viruses does HCV belong to?_____

Answer: Flavivirus

Flashcard 49: What type of vaccine is the HBV vaccine? _____

Answer: Subunit

Flashcard 50: Why does HCV have a lack of proofreading ability and thus displays antigenic variation?_____

Answer: lack of 3'-5' exonuclease

Flashcard 51: Hepatitis C virus can be transmitted through _____ sticking or sharing

Answer: needle

Flashcard 52: Does hepatitis A virus induce a carrier state in infected individuals?_____

Answer: No

Flashcard 53: The genome of the HBV intermediate from dsDNA is _____

Answer: + ssRNA

Flashcard 54: Does hepatitis C have an envelope?_____

Answer: Yes

Flashcard 55: What type of vaccine is the hepatitis A vaccine? _____

Answer: Inactivated/killed

Flashcard 56: Does hepatitis D have an envelope?_____

Answer: Yes

Flashcard 57: What type of virus is Hepatitis B? (DNA, RNA (sense), etc)_____

Answer: Partially double-stranded DNA

Flashcard 58: Which serologic marker is detectable due to immunization to HBV?_____

Answer: Anti-HBs IgG

Flashcard 59: What HBV antigen is positive in neonates with infection acquired at birth?_____

Answer: HBeAg

Flashcard 60: Where does hepatitis B virus replicate? (cytoplasm, nucleus, etc.)_____

Answer: Both Nucleus and Cytoplasm

Flashcard 61: Hepatitis B is from the _____ family

Answer: hepadnavirus