Crohn's disease pathophysiology — Flashcards

Flashcard 1: Crohn disease most commonly involves the _____

Answer: terminal ileum

Flashcard 2: In Crohns disease, loss of the innate barrier function of the intestinal mucosa allows intestinal microbes to induce an exaggerated response by the _____, resulting in chronic GI inflammation

Answer: adaptive immune system

Flashcard 3: Smoking increases risk for _____ (IBD)

Answer: Crohn disease

Flashcard 4: Extraintestinal manifestations of IBD include _____, such as ankylosing spondylitis, sacroiliitis, migratory polyarthritis, and peripheral joints

Answer: arthritis

Flashcard 5: One complication of Crohn disease is a _____, which can cause bowel contents to drain to the surface of the skin

Answer: enterocutaneous fistula

Flashcard 6: Complications of both ulcerative colitis and Crohn disease include malabsorption and _____ cancer

Answer: colorectal

Flashcard 7: Which form of IBD is associated with perianal disease, phlegmon/abscess formation, and strictures? _____

Answer: Crohn disease

Flashcard 8: Which immunodeficiency presents with bone fractures from minor trauma? _____

Answer: Job (hyper-IgE) syndrome

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Flashcard 9: Which form of inflammatory bowel disease typically spares the rectum? _____

Answer: Crohn disease

Extra:   https://onlinemeded.org/spa/gastroenterology/ibd/acquire?ref=anki Atlas: 

Flashcard 10: What HLA subtype is associated with multiple sclerosis? _____

Answer: DR2

Extra:  https://onlinemeded.org/spa/immunology?ref=anki