Compartmentalization between mitochondria and cytosol — Flashcards

Flashcard 1: Where in the cell is the carbamoyl phosphate synthetase I enzyme found?_____

Answer: Mitochondria (urea cycle)

Flashcard 2: In the liver, _____ may transfer a molecule of NH3 to the urea cycle, reforming -ketoglutarate

Answer: glutamate

Flashcard 3: Ornithine transcarbamylase (OTC) deficiency presents with increased _____ acid in the blood and urine

Answer: orotic

Flashcard 4: Most disorders of the urea cycle require _____ as an essential amino acid, particularly during episodes of hyperammonemia

Answer: arginine

Flashcard 5: What is the rate-limiting enzyme of the urea cycle? _____

Answer: Carbamoyl phosphate synthetase I

Flashcard 6: What enzyme converts Urea into Ammonia?_____

Answer: Urease

Flashcard 7: Where does the urea cycle occur?

Answer: steps in both the cytoplasm and mitochondria

Flashcard 8: urea cycle

Answer: carbomoyl phosphate synthetase I

Flashcard 9: What is the overall purpose of the urea cycle?

Answer: to get NH4+ from amino acid catabolism into an excretable form

Flashcard 10: carbomoyl phosphate synthetase I

Answer: urea cycle

Extra: N-acetylglutamate