G-protein coupled receptors US Medical PG Flashcards - Medical Study Cards
Master G-protein coupled receptors with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
G-protein coupled receptors Flashcard Deck - 10 Cards
Flashcard 1: The intrinsic GTPase activity of Ras can be stimulated by _____
Answer: GTPase Activating Proteins (GAPs)
Flashcard 2: One type of receptor tyrosine kinase is a _____, which dimerizes and auto-phosphorylates upon binding of a hormone or ligand
Answer: monomer
Flashcard 3: Newly synthesized cGMP (from guanylyl cyclase activity) activates _____, which phosphorylates specific proteins responsible for physiologic actions
Answer: protein kinase G
Flashcard 4: G proteins have _____ subunits (number of subunits)
Answer: three
Flashcard 5: What type of receptor do growth hormones use for their signaling pathways? _____
Answer: Receptor associated tyrosine kinases
Flashcard 6: _____ facilitate dissociation of GDP so that GTP can bind more rapidly, increasing the rate of G protein activation
Answer: Guanine nucleotide releasing factors (GRFs)
Flashcard 7: NADPH oxidase
Answer: respiratory burst
Extra: O2 O2-
Flashcard 8: Give the pathway by which glucagon/Epi regulate glycogen.
Answer: glucagon/Epi, adenylyl cyclase, cAMP, protein kinase A, glycogen phosphorylsae kinase, glycogen phosphorylase
Flashcard 9: Give the pathway by which insulin regulates glycogen.
Answer: insulin, tyrosine kinase receptor, protein phosphatases, inactivated glycogen phosphorylase kinase and glycogen phorphorylase
Flashcard 10: If an enyzme is a kinase, what do you know about its function?
Answer: uses ATP to add phosphate group to substrate
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