Lysosome structure and function US Medical PG Flashcards - Medical Study Cards
Master Lysosome structure and function with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Lysosome structure and function Flashcard Deck - 9 Cards
Flashcard 1: _____ is a lysosomal storage disease caused by frameshift mutations.
Answer: Tay-Sachs
Flashcard 2: After adipose stores have been depleted (prolonged starvation), vital _____ degradation accelerates, leading to organ failure and death
Answer: protein
Flashcard 3: Which enzyme phosphorylates mannose in the Golgi apparatus, facilitating protein trafficking? _____
Answer: Phosphotransferase
Flashcard 4: Proinsulin is packaged in secretory granules in the _____
Answer: Golgi apparatus
Flashcard 5: _____ have membrane bound organelles and nuclei
Answer: Eukaryotes (Prokaryotes or Eukaryotes)
Flashcard 6: Describe, in general, the lysosomal storage diseases.
Answer: Diverse group of diseases resulting from defects in lysosomal enzymes, characterized by an accumulation of abnormal metabolic products within cells.
Flashcard 7: Pompe's disease (GSD type II)
Answer:
Extra: heart, liver, muscle manifestations, esp. cardiomegaly; early death AR lysosomal α-1,4-glucosidase (acid maltase) mnemonic: Very Bad Carbohydrate Metabolism (the glycogen storage diseases in order)
Flashcard 8: Where does mannose-6-phosphate tagging occur?
Answer: Golgi
Flashcard 9: A mannose-6-phosphate tag targets proteins for where?
Answer: lysosome
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