Rate-limiting enzymes and control points — Flashcards

Flashcard 1: Hexokinase is characterized by a _____ Vmax relative to glucokinase

Answer: low

Flashcard 2: Hexokinase is regulated via negative feedback by _____

Answer: glucose-6-phosphate

Flashcard 3: Fructose bisphosphatase-2 and phosphofructokinase-2 are the same bifunctional enzyme whose function is reversed by phosphorylation by _____

Answer: protein kinase A

Flashcard 4: Glucokinase is regulated via negative feedback by _____

Answer: fructose-6-phosphate

Flashcard 5: Is hexokinase activity inhibited by glucose-6-phosphate? _____

Answer: Yes

Flashcard 6: Which glycolysis enzyme deficiency is the second most common cause of hemolytic anemia? _____

Answer: Pyruvate kinase deficiency

Flashcard 7: phosphofructokinase-2/fructose bisphosphatase-2 (PFK-2/FBP-2)

Answer:

Extra: balances glycolysis and gluconeogenesisF-2,6-BP

Flashcard 8: Where does glycolysis take place?

Answer: cytoplasm

Flashcard 9: glycolysis

Answer: phosphofructokinase-1 (PFK-1)

Flashcard 10: What enzyme converts pyruvate to lactate?

Answer: lactate dehydrogenase (LDH)