Mismatch repair US Medical PG Flashcards - Medical Study Cards
Master Mismatch repair with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Mismatch repair Flashcard Deck - 10 Cards
Flashcard 1: Xeroderma Pigmentosum is an inherited pathology due to a defective _____ pathway
Answer: Nucleotide Excision Repair
Flashcard 2: Mechanisms to repair _____ breaks are defective in Ataxia telangiectasia, Fanconi anemia, and SCID
Answer: dsDNA
Flashcard 3: What form of DNA repair fixes mutations due to DNA replication errors?_____
Answer: mismatch repair
Flashcard 4: What are the four mechanisms of DNA repair?
Answer: Nuceotide excision repair
Base excision repair
Mismatch repair
Nonhomologous end joining
Flashcard 5: non-homologous end joining
Answer: join 2 dsDNA ends
Extra: double-stranded breaks (when no homologous chromosome is around to use as a guide) ataxia telangiectasia
Flashcard 6: mismatch repair
Answer: 1. new strand recognized (lacks methylation)
2. mismatched nucleotides removed
3. DNA pol/ligase fills/seals gap
Extra: Mismatched bases on newly synthesized DNA strand hereditary nonpolyposis colorectal cancer (HNPCC)
Flashcard 7: base excision repair (BER)
Answer: 1. specific glycosylases recognize and remove damaged bases
2. AP endonuclease removes AP DNA
3. DNA pol/ligase fill/seal gap
Extra: spontaneous/toxic changes to the base itself; most often deamination
Flashcard 8: nucleotide excision repair (NER)
Answer: 1. endonuclease removes short ssDNA segment containing lesion
2. DNA pol/ligase fill/seal gap
Extra: bulky adducts, commonly thymine dimers caused by UV radiation xeroderma pigmentosa
Flashcard 9: Is homologous recombination error prone?
_____
Answer: No
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-mutations-damage-and-repair?index=6]
https://onlinemeded.org?ref=anki
Flashcard 10: BRCA1 and BRCA2 are tumor suppresors that are involved in mediating the _____ pathway of DNA repair
Answer: Homologous Recombination
Extra:
Watch Pancreatic Cancer & Islet Cell Tumors [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-neuro/videos/medical-pathophysiology-neuro-intracranial-hypertension-and-tumors-adult-cns-tumors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pathology/videos/cellular-injury-and-neoplasia?index=10]
https://onlinemeded.org?ref=anki
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