Rheumatology & Haematology — Flashcards

What are the initial investigations for suspected haemophilia? _____

Hint: 2

_____ alleles encode for the x2 α-globin chain 2 alleles encode the x2 β-globin chains

Hint: number

An italian patient presents with fatigue, pallor, & tiredness with microcytic hypochromic RBCs and normal iron studies and ↓ RDW. What is the next step? _____

Hint: next step?

Beta thalassaemia _____ is due to β/β+ or β/β0 and presents asymptomatically

Beta thalassaemia _____ is due to β0/β0 and presents with severe anaemia that is transfusion-dependent

Essential thrombocythaemia typically occurs at age _____-60 years old

Public Health England recommend all _____ women are screened for thalassaemia

_____ thalassaemia is usually due to gene mutations Alpha thalassaemia is usually due to gene deletions

The _____ index is used to distinguish iron deficiency anaemia vs minor thalassaemia

A young boy presents with heamarthrosis and easy bruising. Coagulation studies reveal ↑ aPTT & normal PT. Mixing studies are corrected. You suspect haemophilia. What other bleeding disorder must be ruled out? _____