Drug Interactions — Flashcards

Flashcard 1: Which one of the following drugs is a cytochrome p450 inducer? _____

Answer: Rifampin

Flashcard 2: route of administration of Ty21a vaccine is _____

Answer: oral

Extra: 

Flashcard 3: _____ serves as both substrate and inhibitor for CYP2C19.

Answer: Omeprazole

Flashcard 4: Barbiturates are an _____ of cytochrome P450 and thus may have many drug interactions

Answer: inducer

Flashcard 5: The H2 receptor antagonist _____ is a potent inhibitor of cytochrome P-450 and therefore has multiple drug interactions

Answer: cimetidine

Flashcard 6: If patients with _____ are given aminopenicillins (amoxicillin, ampicillin),a maculopapular rash will develop days to weeks after

Answer: Epstein-Barr Virus

Flashcard 7: Antihistamines_____ generation H1 receptor antagonists may acutely suppress the extrapyramidal side effects associated with certain anti-psychotic drugs

Answer: 1st

Flashcard 8: Theophylline increases the effects of _____ by activating enzyme histone deacetylase

Answer: steroids

Flashcard 9: Dyslipidemia drugs _____ are lipid-lowering agents that may decrease the absorption of statins, thus these drugs should be given 4 hours apart

Answer: Bile acid resins

Flashcard 10: Phenytoin is an _____ of cytochrome P450 and thus may have many drug interactions

Answer: inducer

Flashcard 11: The effects of 5-fluorouracil can be _____ with leucovorin

Answer: potentiated

Flashcard 12: _____ generation sulfonylureas (e.g. chlorpropamide, tolbutamide) may cause a disulfiram-like reaction as a possible side effect when you ingest alcohol while taking these drugs

Answer: 1st

Flashcard 13: Cardiovascular (Antiarrhythmics) _____, a class III antiarrhythmic, is an inhibitor of cytochrome P450 and thus may have many drug interactions

Answer: Amiodarone

Flashcard 14: Coadministration of _____ and cocaine is known as 'beam me up'.

Answer: Phencyclidine

Flashcard 15: Aliskiren is relatively contraindicated in patients already taking _____ or ARBs

Answer: ACE inhibitors

Flashcard 16: Renal clearance of digoxin is decreased with antiarrhythmic drugs such as _____, amiodarone, and quinidine

Answer: verapamil

Flashcard 17: _____ is an antimicrobial that can cause a disulfiram-like reaction with concurrent alcohol use

Answer: Metronidazole

Flashcard 18: Which antibiotics are chelated by cations (Ca2+, Fe2+, Mg2+)?_____

Answer: Tetracyclines

Flashcard 19: Metoclopramide has drug interactions with _____ and diabetic agents

Answer: digoxin

Flashcard 20: Carbamazepine is an _____ of cytochrome P450 and thus may have many drug interactions

Answer: inducer

Flashcard 21: Fibrates may cause _____ as an adverse effect, especially when combined with statins

Answer: myopathy

Flashcard 22: Because _____ induces CYP450 less than other drugs in its class (ie: Rifampin),it is used in the treatment of tuberculosis in HIV patients

Answer: Rifabutin

Flashcard 23: _____ diuretics may decrease renal excretion of lithium, which is commonly used as an anti-psychotic drug

Answer: Thiazide

Flashcard 24: Vitamin _____ can enhance the anticoagulant effects of warfarin

Answer: E

Flashcard 25: Rifampin is a CYP450 _____ and thus is contraindicated in HIV due to it decreasing HIV protease inhibitor serum concentrations

Answer: activator

Flashcard 26: Coadministration of ACE inhibitors with _____ can precipitate acute kidney injury

Answer: NSAIDs

Flashcard 27: Aspirin and Ibuprofen can displace _____ hormones from binding proteins and should be avoided in patients with hyperthyroidism

Answer: thyroid

Flashcard 28: Neuro/Psych_____ agonists can cause opioid withdrawal symptoms if the patient is also taking a full opioid agonist

Answer: Partial opioid

Flashcard 29: Simeprevir is an _____ of cytochrome P450 and thus may have many drug interactions

Answer: inhibitor

Flashcard 30: _____ can be inactivated by various penicillins in vitro and thus should not be admixed in solution before administration

Answer: Aminoglycosides

Flashcard 31: Cardiovascular (Antiarrhythmics) _____ is an antiarrhythmic that is less effective in the presence of theophylline and caffeine (methylxanthines)

Answer: Adenosine

Flashcard 32: _____ dose of 6-mercaptopurine (6MP) requires reduction by 75% when administered with allopurinol.

Answer: Oral

Flashcard 33: Allopurinol inhibits the breakdown of purine analogs (ie: _____ and azathioprine)

Answer: 6-mercaptopurine

Flashcard 34: All _____ class of local anesthetics produces para-aminobenzoic acid which antagonizes the sulphonamides.

Answer: ester

Flashcard 35: First Aid Pharmacology: Calcium Channel Blockers (CCBs) _____ CCBs may cause excessive AV block when combined with beta-adrenergic antagonists

Answer: Non-dihydropyridine

Flashcard 36: Vitamin B6 deficiency may occur with _____ and oral contraceptive use

Answer: isoniazid

Flashcard 37: Which antibiotics (2) should be not be taken with antacids, milk, or ferrous sulfate?_____

Answer: Tetracyclines

Flashcard 38: _____ is a pharmacological booster with no antiretroviral activity.

Answer: Cobicistat

Flashcard 39: Broad-spectrum antibiotics suppress the intestinal flora and interfere with the _____ of estrogen, thus leading to OCP failure

Answer: enterohepatic circulation

Flashcard 40: Can Ty21a be given to patients taking antibacterial medication?_____

Answer: No

Flashcard 41: Which lipid lowering drug increases binding of thyroid hormone to TBG?_____

Answer: Clofibrate

Flashcard 42: Are potassium-sparing diuretics advised with ACE Inhibitors?_____

Answer: No

Flashcard 43: Telavancin should be avoided with any drugs that _____ the QTc interval

Answer: prolong

Flashcard 44: The omission of prior diuretic dose _____ the risk of postural hypotension in patients being started on ACEI therapy

Answer: decreases (decreases/increases)

Flashcard 45: Myopathy risk is highest when statins are used along with _____.

Answer: gemfibrozil

Flashcard 46: Enzyme _____ increase the metabolism of oral contraceptives and can cause contraceptive failure

Answer: inducers

Flashcard 47: Drug antagonism between heparin and protamine sulfate is an example of _____ antagonism.

Answer: chemical

Flashcard 48: The minimum duration of time between the consumption of phenytoin and sucralfate should be _____ minutes.

Answer: 120

Flashcard 49: How does Pyridoxine reduce the effectiveness of levodopa?_____

Answer: By potentiating its peripheral conversion by dopa decarboxylase

Flashcard 50: _____ is a weak MAOI and can cause Serotonin syndrome on concurrent administration with SSRIs

Answer: Linezolid

Flashcard 51: _____ causes anterior uveitis when used along with clarithromycin.

Answer: Rifabutin::ATT

Flashcard 52: Voriconazole inhibits and Diclofenac is metabolised by CYP_____

Answer: 2C9

Flashcard 53: _____ can be safely prescibed alongside statins

Answer: Beta blockers::Anti hypertensives

Flashcard 54: Allopurinol decreases the clearance of theophylline by inhibition of CYP_____

Answer: 1A2