Beta-Lactam Antibiotics — Flashcards

The mnemonic CAMPFIRE can be used to remember the drugs effective against Pseudomonas aeruginosa_____AminoglycosidesMonobactams (aztreonam)Polymixins (polymixin B, colistin)Fluoroquinolones (cipro, levofloxacin)thIRd and fourth-gen cephalosporins (ceftazidime, cefepime)Extended spectrum (antipseudomonal) penicillins (piperacillin, ticarcillin)

Penicillins are effective against the thick peptidoyglycan cell walls ofgram _____ bacteria (ie: Staphylococcus spp. and Streptococcus spp.)

_____ are anti-bacterials that have bulky R-groups that block access of -lactam ring, making them penicillinase/beta-lactamase resistant.

Resistance of penicillins comes from production of _____ that cleave the -lactam ring,or changes to penicillin binding proteins (confers methicillin resistance in MRSA).

Penicillins can result in type _____ hypersensitivity reactions, mediated by IgE causing anaphylaxis

2nd generation cephalosporins have the same coverage as _____ generation cephalosporins with extended gram-negative coverage

Which group of modified penicillins is associated with the following rash? _____

Beta-lactams (ie: penicillin, cephalosporins, etc.) work by halting _____ synthesisvia inhibition of penicillin-binding proteins (PBPs) transpeptidase activity

Monobactams lack cross-sensitivity with the other beta-lactams except for _____

Which step ([A] - [E]) of Bacterial Protein Synthesis do Aminoglycosides inhibit? _____