Principles of Cancer Chemotherapy — Flashcards

Present chemotherapy regimen used for breast cancer is ACT, i.e., _____, Cyclophosphamide, and Taxane (Paclitaxel)

Proteasomal inhibitors (_____) are antineoplastics that inhibit cell cycle progression at the G2-M phase

Hint: suffix

Anthracyclines (doxorubicin, daunorubicin) _____ into DNA, blocking DNA and RNA synthesis

Platinum based antineoplastics can cause side effects which might make ya say NOPE- _____, in particular Acute Tubular Necrosis- Ototoxicity- Peripheral Neuropathy- Emesis

-Posides (Topoisomerase II inhibitor antineoplastics) are used to treat solid tumors, particularly _____ cancer and small cell lung cancer

Methotrexate resistance is due to the overproduction of _____

The effects of 5-fluorouracil can be _____ with leucovorin

What cell cycle phase does 5-FU act at in lower doses?_____

Cerebellar toxicity is seen with which anti-cancer drug?_____

Antineoplastic agents extracted from the Periwinkle plant is: _____ also called Catharanthus roseus