Alkylating Agents — Flashcards

Nitrosoureas are _____directly acting carcinogens

Alkylating agents donate an _____ group that cross-links DNA, resulting in cell apoptosis

Cyclophosphamide use can result in _____, with the bladder toxicity arising from the metabolite acrolein

Which alkylating agent is used as the first line therapy for management of glioblastoma multiforme?_____

Sustained neutropenia is seen with _____

Amifostine scavenges _____ produced by cisplatin in the kidney

Anthracyclines (doxorubicin, daunorubicin) form _____ which cause breaks in DNA

Antineoplastic agents extracted from the Periwinkle plant is: _____ also called Catharanthus roseus

_____ is a monoclonal antibody against PDGFR- and blocks ligand-mediated receptor activation

Cetuximab is a monoclonal antibody against the _____ Receptor most commonly used to treat Stage IV colorectal cancer