Genetic Basis of Cancer — Flashcards

ER/PR-_____, HER2-negative cancers is the most common subtype of breast cancer in individuals who inherit germline mutations in BRCA2

The tumor suppressors encoded by the CDKN2A gene enforce the G1-->S restriction point by:(1) - inhibiting CDK_____/6 (2) - relieving inhibition of P53

Loss of copies of a tumor suppressor gene (knudson two-hit hypothesis) arise from _____ (inherited) or somatic (sporadic) mutations

The KIT _____ encodes for the Stem Cell Factor receptor, which when bound leads to cell growthThis is a growth factor receptor found commonly in GI stromal tumor

Mutations that cause _____ of the PDGFB proto-oncogene can precipitate development of an Astrocytoma by creating an autocrine loop

_____ is due to an inherited mutation in the APC gene on chromosome 5q

Wilms tumor is caused by "loss of function" mutations of tumor suppression genes _____ or WT2 on chromosome 11

Lynch syndrome is associated with increased risk for _____, endometrial, ovarian, and skin cancers

The following image represents the _____ carcinoma subtype of invasive ductal carcinoma (breast): hint: the circled area is lymphatics

In HPV-_____ SCC of the oral cavity, patients generally present with large primary lesions with variable nodal disease.