Principles of Molecular Pathology — Flashcards

_____ is the most commonly mutated gene in sporadic breast carcinomas

Activating mutation in _____ is responsible for bladder carcinoma.

In Array based Comparative Genomic Hybridization, if the test sample has deletion, then some spots on the array will flouresce _____

HER2-_____ cancers are most common subtype of breast cancer in patients with germline mutations in TP53 (Li Fraumeni syndrome)

_____ pattern of staining represents antibodies to RNA

What is the mechanism that results in malignancy from the ABL oncogene?_____

Point mutation of _____ protein is seen in uveal melanoma.

_____ disease is due to a deletion of the VHL gene on chromosome 3p, leading unregulated activity of HIF1a

Mutations that cause _____ of the HER2 receptor can precipitate development of certain Breast* and Gastric* Cancers by amplifying the signal transduction

_____ syndrome is most commonly characterized by a 47,XXY karyotype