Next-Generation Sequencing — Flashcards

_____ is the most commonly mutated gene in sporadic breast carcinomas

A _____ score is calculated using the molecular tests for breast cancer, ranging from 0-100

Mutations of the _____ gene in 97% of adult granulosa cell tumors

In Array based Comparative Genomic Hybridization, if the test sample has deletion, then some spots on the array will flouresce _____

Best method for detection of mutation with low allele frequency is _____ PCR

_____ is a molecular test in breast cancer that is a 70-gene assay

_____ syndrome is most commonly characterized by a 47,XXY karyotype

_____ disease is due to a deletion of the VHL gene on chromosome 3p, leading unregulated activity of HIF1a

Mutations that cause _____ of the HER2 receptor can precipitate development of certain Breast* and Gastric* Cancers by amplifying the signal transduction

Over 85% of mutations in the FGFR3 gene occur _____ and are related to increased paternal age