Paracortical hyperplasia is caused by stimuli that trigger _____-cell mediated immune responses (eg. viral infections)
#2
_____ is the most serious form of combined immunodeficiency.
#3
What HLA subtypes are associated with type I diabetes mellitus? _____ and DR4
#4
Nude mice is not resistant to xenograft due to absence of _____.
#5
VKC is primarily a type _____ hypersensitivity reaction, but also involves type 4
#6
LE cell is a phagocytic _____ or _____ that has engulfed the denatured nucleus of an injured cell
#7
--- Do with heme ---
Type II Hypersensitivity Disorders - Cytotoxic:
Transfusion Reaction
- Antibody against _____
- IgM isohemagglutinins formed naturally in response to bacterial flora cause opsonization and complement activation
- Leads to hemolysis
**Hemolytic Disease of the Newborn (Erythroblastosis fetalis)
Antibody = _____
- Formed in _____ mother carrying _____ child
- First pregnancy _____ (doesn't have to be viable pregnancy)
- Antibody crosses placenta and injures subsequent fetuses
- Prevent with _____ (anti-Rh, binds fetal red cells and prevents mothers immune system from reacting)
ABO blood typing and screening for other preformed Abs; always done in case of transplants.
Universal donor: type _____
Universal recipient: type _____
(Ex) Type A can donate to _____ and _____. Type A can receive donations from _____ and _____.
- Anti-B antibodies prevent donation from type B and type AB.
HLA Typing - Microcytotoxicity test
Tests for MHC _____
Test hundreds of different haplotypes to find a potential match.
Cells recognized by antibody will be attacked by complement and thus become leaky and take up dye.
HLA Typing - Mixed lymphocyte reaction
Tests for MHC class _____
Take donor cells and irradiate them (prevent proliferation). Irradiated cells are mixed with donor cells to see if proliferation occurs.
Higher radioactivity (thymidine) signifies _____ compatibility.
#8
_____ cells are plasma cells characterized by the accumulation of multiple Russell bodies
#9
_____ is caused by a defect in the BTK gene
#10
B-cell activation requires a costimulatory signal from binding between the _____ (B cell) and CD40 ligand (Th2 cell)
Transplantation Immunopathology Indian Medical PG Flashcards - Medical Study Cards
Master Transplantation Immunopathology with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Flashcard 1: Paracortical hyperplasia is caused by stimuli that trigger _____-cell mediated immune responses (eg. viral infections)
Answer: T
Flashcard 2: _____ is the most serious form of combined immunodeficiency.
Answer: Reticular dysgenesis
Flashcard 3: What HLA subtypes are associated with type I diabetes mellitus? _____ and DR4
Answer: DR3
Flashcard 4: Nude mice is not resistant to xenograft due to absence of _____.
Answer: T cell
Flashcard 5: VKC is primarily a type _____ hypersensitivity reaction, but also involves type 4
Answer: 1
Flashcard 6: LE cell is a phagocytic _____ or _____ that has engulfed the denatured nucleus of an injured cell
Answer: neutrophil
Flashcard 7: --- Do with heme ---
Type II Hypersensitivity Disorders - Cytotoxic:
Transfusion Reaction
- Antibody against _____
- IgM isohemagglutinins formed naturally in response to bacterial flora cause opsonization and complement activation
- Leads to hemolysis
**Hemolytic Disease of the Newborn (Erythroblastosis fetalis)
Antibody = _____
- Formed in _____ mother carrying _____ child
- First pregnancy _____ (doesn't have to be viable pregnancy)
- Antibody crosses placenta and injures subsequent fetuses
- Prevent with _____ (anti-Rh, binds fetal red cells and prevents mothers immune system from reacting)
ABO blood typing and screening for other preformed Abs; always done in case of transplants.
Universal donor: type _____
Universal recipient: type _____
(Ex) Type A can donate to _____ and _____. Type A can receive donations from _____ and _____.
- Anti-B antibodies prevent donation from type B and type AB.
HLA Typing - Microcytotoxicity test
Tests for MHC _____
Test hundreds of different haplotypes to find a potential match.
Cells recognized by antibody will be attacked by complement and thus become leaky and take up dye.
HLA Typing - Mixed lymphocyte reaction
Tests for MHC class _____
Take donor cells and irradiate them (prevent proliferation). Irradiated cells are mixed with donor cells to see if proliferation occurs.
Higher radioactivity (thymidine) signifies _____ compatibility.
Answer: ABO blood glycoproteins
Flashcard 8: _____ cells are plasma cells characterized by the accumulation of multiple Russell bodies
Answer: Mott
Flashcard 9: _____ is caused by a defect in the BTK gene
Answer: X-linked (Bruton) agammaglobulinemia
Flashcard 10: B-cell activation requires a costimulatory signal from binding between the _____ (B cell) and CD40 ligand (Th2 cell)
Answer: CD40 receptor
Keywords: Transplantation Immunopathology flashcards, medical flashcards, NEET PG preparation, USMLE Step 1 flashcards, Anki alternative, spaced repetition medical, OnCourse flashcards
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