Vascular rejection in organ graft is a type of type _____ hypersensitivity reaction*mechanism?
#2
Classical immunophenotypic feature of CLL on Flow cytometry is CD 19+, CD20+, CD _____, CD _____
#3
_____ is a IHC marker seen with Breast carcinoma, urothelial carcinoma, salivary duct carcinoma and choriocarcinoma
#4
The most common antibodies associated with TRALI are those that bind particularly _____ antigens
#5
Monocytoid B cells in sinuses are seen in _____ stages of HIV infection
#6
The _____ Coombs test adds anti-human globulin (Coombs reagent) to a sample of a patient's RBCs
#7
_____ is phagocytosis of apoptotic bodies done by macrophages, epithelial cells, and fibroblast cells.
#8
LE cell is a phagocytic _____ or _____ that has engulfed the denatured nucleus of an injured cell
#9
--- Do with heme ---
Type II Hypersensitivity Disorders - Cytotoxic:
Transfusion Reaction
- Antibody against _____
- IgM isohemagglutinins formed naturally in response to bacterial flora cause opsonization and complement activation
- Leads to hemolysis
**Hemolytic Disease of the Newborn (Erythroblastosis fetalis)
Antibody = _____
- Formed in _____ mother carrying _____ child
- First pregnancy _____ (doesn't have to be viable pregnancy)
- Antibody crosses placenta and injures subsequent fetuses
- Prevent with _____ (anti-Rh, binds fetal red cells and prevents mothers immune system from reacting)
ABO blood typing and screening for other preformed Abs; always done in case of transplants.
Universal donor: type _____
Universal recipient: type _____
(Ex) Type A can donate to _____ and _____. Type A can receive donations from _____ and _____.
- Anti-B antibodies prevent donation from type B and type AB.
HLA Typing - Microcytotoxicity test
Tests for MHC _____
Test hundreds of different haplotypes to find a potential match.
Cells recognized by antibody will be attacked by complement and thus become leaky and take up dye.
HLA Typing - Mixed lymphocyte reaction
Tests for MHC class _____
Take donor cells and irradiate them (prevent proliferation). Irradiated cells are mixed with donor cells to see if proliferation occurs.
Higher radioactivity (thymidine) signifies _____ compatibility.
#10
_____ cells are plasma cells characterized by the accumulation of multiple Russell bodies
Immunologic Laboratory Techniques Indian Medical PG Flashcards - Medical Study Cards
Master Immunologic Laboratory Techniques with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Flashcard 1: Vascular rejection in organ graft is a type of type _____ hypersensitivity reaction*mechanism?
Answer: II
Flashcard 2: Classical immunophenotypic feature of CLL on Flow cytometry is CD 19+, CD20+, CD _____, CD _____
Answer: 23+; 5+
Flashcard 3: _____ is a IHC marker seen with Breast carcinoma, urothelial carcinoma, salivary duct carcinoma and choriocarcinoma
Answer: GATA3
Flashcard 4: The most common antibodies associated with TRALI are those that bind particularly _____ antigens
Answer: MHC class I
Flashcard 5: Monocytoid B cells in sinuses are seen in _____ stages of HIV infection
Answer: early
Flashcard 6: The _____ Coombs test adds anti-human globulin (Coombs reagent) to a sample of a patient's RBCs
Answer: direct
Flashcard 7: _____ is phagocytosis of apoptotic bodies done by macrophages, epithelial cells, and fibroblast cells.
Answer: Efferocytosis
Flashcard 8: LE cell is a phagocytic _____ or _____ that has engulfed the denatured nucleus of an injured cell
Answer: neutrophil
Flashcard 9: --- Do with heme ---
Type II Hypersensitivity Disorders - Cytotoxic:
Transfusion Reaction
- Antibody against _____
- IgM isohemagglutinins formed naturally in response to bacterial flora cause opsonization and complement activation
- Leads to hemolysis
**Hemolytic Disease of the Newborn (Erythroblastosis fetalis)
Antibody = _____
- Formed in _____ mother carrying _____ child
- First pregnancy _____ (doesn't have to be viable pregnancy)
- Antibody crosses placenta and injures subsequent fetuses
- Prevent with _____ (anti-Rh, binds fetal red cells and prevents mothers immune system from reacting)
ABO blood typing and screening for other preformed Abs; always done in case of transplants.
Universal donor: type _____
Universal recipient: type _____
(Ex) Type A can donate to _____ and _____. Type A can receive donations from _____ and _____.
- Anti-B antibodies prevent donation from type B and type AB.
HLA Typing - Microcytotoxicity test
Tests for MHC _____
Test hundreds of different haplotypes to find a potential match.
Cells recognized by antibody will be attacked by complement and thus become leaky and take up dye.
HLA Typing - Mixed lymphocyte reaction
Tests for MHC class _____
Take donor cells and irradiate them (prevent proliferation). Irradiated cells are mixed with donor cells to see if proliferation occurs.
Higher radioactivity (thymidine) signifies _____ compatibility.
Answer: ABO blood glycoproteins
Flashcard 10: _____ cells are plasma cells characterized by the accumulation of multiple Russell bodies
