Defects in Signal Transduction and Disease — Flashcards

In the adenylyl cyclase mechanism of cellular signaling, the second messenger _____ activates protein kinase A, which then phosphorylates specific proteins to produce physiologic actions

Gi proteins _____ the cAMP signaling cascade

_____ activates guanylyl cyclase in the gut, thereby increasing cGMP secretion

Hint: Heat labile or Heat stable toxin

PTCH1 is a membrane receptor and a _____ regulator of the Hedgehog signaling pathway.

Hint: positive/negative

_____ often presents with increased levels of urinary cAMP due to the activation of Gs proteins when PTH binds its receptor

The alpha subunit of G proteins has intrinsic _____ activity and may bind GDP (inactive) or GTP (active)

Growth factor binding to receptor results in Ras replacing _____ with GTP

The events that occur during the activation of GPCR are as follows: No answer _____

Cyclin _____ and Cyclin E-CDK2 drive cells from G1 to S phase

Cyclin _____ and Cyclin A-CDK1 are active in S phase