Pyrimidine Metabolism and Disorders — Flashcards

_____ inhibits ribonucleotide reductase, which normally catalyzes conversion of UDP to dUDP (pyrimidine synthesis)

In the first step of pyrimidine synthesis, glutamine and CO2 are combined to form _____ via the enzyme carbamoyl phosphate synthetase II (requires 2 ATP)

The only mitochondrial step in pyrimidine synthesis is catalyzed by the enzyme _____

Pyrimidine synthesis begins with _____, CO2, and 2 ATP

The _____ is the site where RNA polymerase II and general transcription factors bind to DNA upstream from a gene locus

microRNA often leads to the _____ of target mRNA, thus causing decreased translation into protein

Hypoxanthine is converted to _____ via xanthine oxidase

Guanosine is converted to _____ via the enzyme purine nucleoside phosphorylase (purine salvage)

Which base excision repair enzymes are responsible for filling and sealing the gap from the excised bases?_____ (filling) and DNA ligase III (sealing)

Hint: specific

Xanthine is converted to _____ by xanthine oxidase