Purine Metabolism and Disorders — Flashcards

The enzyme _____ is an important enzyme for de novo purine production, which converts PRPP to an intermediate used in the generation of IMP

Glutamine-PRPP amidotransferase (purine synthesis) is regulated by negative feedback via _____, IMP, and GMP

The disadvantage of using CDPA-1 is that it increases _____ stone formation.

Besides inhibiting Thymidine production, THF is also involved in the formation of _____, as well as some amino acids

Xanthine may be converted to _____ via the enzyme xanthine oxidase

Xanthine is converted to _____ by xanthine oxidase

Guanosine is converted to _____ via the enzyme purine nucleoside phosphorylase (purine salvage)

Hypoxanthine is converted to _____ via xanthine oxidase

Which base excision repair enzymes are responsible for filling and sealing the gap from the excised bases?_____ (filling) and DNA ligase III (sealing)

Hint: specific

The _____ is the site where RNA polymerase II and general transcription factors bind to DNA upstream from a gene locus