Which metabolic pathways require an obligate activator? 1. _____2. Urea cycle
#2
Increased glucagon (fasting) leads to increased cAMP and protein kinase A, thus _____ activity of FBPase-2 and decreasing activity of PFK-2
#3
In starvation, the enzyme 5'-deiodinase is _____ in tissues such as skeletal muscle, but not inhibited in the other tissues, such as the brain
#4
During fasting and starvation, the priority is to supply sufficient glucose to the _____ and RBCs while preserving protein
#5
Effect of diabetes on hepatic glycolysis: no answer _____
- No PFK-2 due to lack of insulin
- No glucose trapping in liver leads to elevated blood glucose (hyperglycemia)
#6
_____ deficiency causes a buildup of pyruvate that gets shunted to lactate (via LDH) and alanine (via ALT)
#7
Increased NADH/NAD+ (e.g. due to ethanol) causes increased conversion of _____ -> malate, thus preventing gluconeogenesis
#8
Glucagon causes _____ fatty acid synthesis and increased lipolysis, which shunts substrates towards gluconeogenesis
#9
Glucagon acts on the _____ (primarily) and adipose tissue
#10
Thyroid hormone increases the processes of _____, gluconeogenesis, proteolysis, and lipolysis, all of which may provide sources of ATP
Obesity: Biochemical Aspects Indian Medical PG Flashcards - Medical Study Cards
Master Obesity: Biochemical Aspects with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Flashcard 1: Which metabolic pathways require an obligate activator? 1. _____2. Urea cycle
Answer: Gluconeogenesis
Flashcard 2: Increased glucagon (fasting) leads to increased cAMP and protein kinase A, thus _____ activity of FBPase-2 and decreasing activity of PFK-2
Answer: increasing
Flashcard 3: In starvation, the enzyme 5'-deiodinase is _____ in tissues such as skeletal muscle, but not inhibited in the other tissues, such as the brain
Answer: inhibited
Flashcard 4: During fasting and starvation, the priority is to supply sufficient glucose to the _____ and RBCs while preserving protein
Answer: brain
Flashcard 5: Effect of diabetes on hepatic glycolysis: no answer _____
- No PFK-2 due to lack of insulin
- No glucose trapping in liver leads to elevated blood glucose (hyperglycemia)
Answer: :)
Flashcard 6: _____ deficiency causes a buildup of pyruvate that gets shunted to lactate (via LDH) and alanine (via ALT)
Answer: Pyruvate dehydrogenase
Flashcard 7: Increased NADH/NAD+ (e.g. due to ethanol) causes increased conversion of _____ -> malate, thus preventing gluconeogenesis
Answer: oxaloacetate
Flashcard 8: Glucagon causes _____ fatty acid synthesis and increased lipolysis, which shunts substrates towards gluconeogenesis
Answer: decreased
Flashcard 9: Glucagon acts on the _____ (primarily) and adipose tissue
Answer: liver
Flashcard 10: Thyroid hormone increases the processes of _____, gluconeogenesis, proteolysis, and lipolysis, all of which may provide sources of ATP
