Liver as Metabolic Hub — Flashcards

RBCs and the _____ cannot utilize ketone bodies.

After three days of starvation, the main source of energy for the brain becomes _____ from adipose stores

Urea cycle and Krebs cycle are linked at _____

Thyroid hormone increases the processes of _____, gluconeogenesis, proteolysis, and lipolysis, all of which may provide sources of ATP

Which metabolic enzymes require an obligate activator? 1. _____2. Carbamoyl phosphate synthetase I (N-acetylglutamate)

Increased glucagon (fasting) leads to increased cAMP and protein kinase A, thus _____ activity of FBPase-2 and decreasing activity of PFK-2

Glucagon causes _____ fatty acid synthesis and increased lipolysis, which shunts substrates towards gluconeogenesis

In a person starving for more than 18 hours, the source of energy is _____.

Effect of diabetes on hepatic glycolysis: no answer _____ - No PFK-2 due to lack of insulin - No glucose trapping in liver leads to elevated blood glucose (hyperglycemia)

Increased NADH/NAD+ (e.g. due to ethanol) causes increased conversion of _____ -> malate, thus preventing gluconeogenesis