Lipid Metabolism — Flashcards

Cholesterol synthesis:Cyclization of _____ to give rise to the parent steroid, lanosterol

Type _____ familial dyslipidemia is due to a defective Apo E allele

Fatty acid synthesis requires _____, which is provided by the HMP shunt and malic enzyme

The _____ receptor on the liver binds to ApoB-100 of the LDL particle, causing subsequent endocytosis

Hepatocytes synthesize _____ using the rate-limiting enzyme HMG CoA reductase

The intestines package _____ and cholesterol esters into chylomicrons, which initially enter the lymph

Adrenal _____, such as DHEA and androstenedione, have a ketone group at C-17 and are excreted as 17-ketosteroids in the urine

Apoprotein _____ is a cofactor and activator of the enzyme LPL (lipoprotein lipase)

The zona _____ normally cannot produce glucocorticoids because it lacks the enzyme 17-hydroxylase

The liver packages _____ and cholesterol into VLDLs, which enter the blood