Heme Synthesis and Porphyrias — Flashcards

Heme Synthesis and Porphyrias — Flashcards

Heme Synthesis and Porphyrias — Flashcards
#1

Lead (Pb) poisoning leads to inhibition of the enzymes _____ and ferrochelatase (heme synthesis)

#2

_____, probably acting through an aporepressor molecule, acts as a negative regulator of the synthesis of ALA Synthase-1 in the hepatic biosynthesis of Heme

#3

Heme is composed of _____ and protoporphyrin

#4

Each subunit of hemoglobin contains a _____ moiety, which is an iron-binding porphyrin, and a polypeptide chain

#5

The enzyme deficient in hereditary coproporphyria is _____.

#6

_____ is the most commonly used indicator for iron in low anemic areas

#7

iron absorption inhibitors are _____

#8

total body iron is _____ gm

#9

1 gm of Hb contains _____ mg iron

#10

In splenic macrophages, heme is metabolized to _____ by the enzyme heme oxygenase

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