Phase I Reactions: Cytochrome P450 System — Flashcards

Phase I Reactions: Cytochrome P450 System — Flashcards

Phase I Reactions: Cytochrome P450 System — Flashcards
#1

The enzyme responsible for conjugation of bilirubin, glucuronyl transferase is mainly located in the _____

#2

Ethanol has many methods of carcinogenic activity including:(1) - metabolites forming DNA _____(2) - depletion of S-adenosylmethionine (SAM)(3) - stimulating the Epithelial-Mesenchymal Transition

#3

Which is the rate-limiting step for the entire process of hepatic bilirubin metabolism?_____

#4

Anti-oxidants can be classified as _____ or preventive

#5

Cytochrome p450 is a _____-oxygenase

#6

In the _____, ethanol may be converted to acetaldehyde via the enzyme catalase

#7

In liver _____, ethanol may be converted to acetaldehyde via the enzyme CYP2E1

#8

In liver, the _____ pathway is the source of glucuronic acid for conjugation of many endogenous and exogenous substances.

#9

Carcinoid tumors often secrete _____, which is dumped into the portal vein and processed by the liver via monoamine oxidase (MAO)

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