Bilirubin Metabolism and Jaundice — Flashcards

Which is the rate-limiting step for the entire process of hepatic bilirubin metabolism?_____

Cytochrome p450 is a _____-oxygenase

_____ conjugation is the only phase II metabolic reaction that is carried out by microsomal enzymes

In liver _____, ethanol may be converted to acetaldehyde via the enzyme CYP2E1

In the _____, ethanol may be converted to acetaldehyde via the enzyme catalase

Anti-oxidants can be classified as _____ or preventive

Carcinoid tumors often secrete _____, which is dumped into the portal vein and processed by the liver via monoamine oxidase (MAO)

In liver, the _____ pathway is the source of glucuronic acid for conjugation of many endogenous and exogenous substances.

_____, a by-product of G6PD, is needed to regenerate reduced glutathione

Ethanol has many methods of carcinogenic activity including:(1) - metabolites forming DNA _____(2) - depletion of S-adenosylmethionine (SAM)(3) - stimulating the Epithelial-Mesenchymal Transition