Disorders of Pigmentation — MCQs

Patient with pigmented skin lesion shows pagetoid spread of atypical melanocytes. Diagnosis?

Wood's lamp is used in the diagnosis of:

A 35-year-old woman consulted a dermatologist due to a persistent facial rash. Physical examination revealed an erythematous rash, without blistering or ulceration, involving both cheeks and the nose, with the nasolabial folds relatively spared. The dermatologist also noted scattered erythematous, firm, maculopapular lesions on the face, neck, upper chest, and elbows, as well as focal alopecia on the scalp. The patient reported that the rash had been present for approximately six months, with exacerbation upon exposure to sunlight. Which autoimmune disease would MOST likely produce this patient's skin problems?

A 77-year-old man has a lesion on the right side of his face that has enlarged slowly over the past 5 years. On examination, the 3-cm lesion has irregular borders, irregular brown to black pigmentation, and a central 2-mm raised blue-black nodule. The lesion is resected and microscopically shows radial growth of large round malignant cells, some isolated and others in nests in the epidermis and superficial papillary dermis. The cells have prominent red nucleoli and dust-like cytoplasmic pigment. Which mutated gene is most likely to be present in the skin lesion of this man?

Langerhans cells in skin are :

Langerhans cells in skin fall under which category?

Which of the following genetic syndromes are associated with brain tumours? 1. Neurofibromatosis type 1 2. Neurofibromatosis type 2 3. Tuberous sclerosis 4. Wiskott-Aldrich syndrome Select the answer using the code given below.

Which of the following is a cause of Hirschsprung disease in a patient?

Mitochondrial abnormalities are associated with which of the following conditions?

A 74-year-old woman has noted increasing size and number of darker brown patches on the dorsum of each hand for the past 15 years. They do not change with sun exposure, are nonpruritic, and non-tender. On examination, these 0.5- to 1-cm lightly pigmented lesions are flat. Which of the following is the most likely microscopic finding in these lesions?