Abdominal aortic aneurysm repair

Abdominal aortic aneurysm repair

Abdominal aortic aneurysm repair

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🧬 The Widening Wall

  • Focal aortic dilation > 3.0 cm or >50% of normal diameter; typically infrarenal.
  • Pathophysiology: Chronic inflammation → ↑Matrix Metalloproteinases (MMPs) → degradation of elastin & collagen → wall weakening.
  • Key Risks: Smoking (strongest), male sex, age >65, family history, atherosclerosis.

⭐ Law of Laplace ($T \propto P \times r$): As AAA radius (r) increases, wall tension (T) increases, driving further expansion and ↑ rupture risk.

🛡️ Pathophysiology - Wall Under Siege

  • Chronic Inflammation: Infiltration of macrophages & T-cells into the aortic wall.
  • Proteolytic Degradation: ↑ Matrix Metalloproteinases (MMPs) & elastases degrade elastin and collagen.
  • Structural Failure: Leads to smooth muscle cell apoptosis and loss of wall integrity.
  • Law of Laplace: Wall tension $T \propto P \times r$. As radius (r) ↑, tension (T) ↑, promoting expansion.

Histology of Aneurysmal vs. Physiological Abdominal Aorta

Location: Most AAAs are infrarenal, likely due to reduced vasa vasorum supply, leading to relative ischemia and wall weakness.

🤫 Clinical Manifestations - The Silent Killer

  • Asymptomatic (Most Common):

    • Usually an incidental finding on imaging.
    • May present as a palpable, pulsatile abdominal mass.
  • Symptomatic (Non-ruptured):

    • Constant, gnawing abdominal, flank, or back pain.
    • Suggests rapid expansion or impending rupture.
  • Ruptured AAA (Classic Triad):

    • Sudden, severe pain.
    • Hypotension/shock.
    • Pulsatile mass.

⭐ The classic triad of rupture (pain, hypotension, pulsatile mass) is present in only ~50% of patients.

📏 Diagnosis - Sizing Up the Threat

  • Initial Test & Screening: Abdominal Ultrasound (US).
  • Pre-op Planning (Gold Standard): CT Angiography (CTA).
    • Defines anatomy: diameter, length, neck morphology, renal/iliac artery involvement.
  • 💡 Aortic diameter > 3.0 cm is defined as an aneurysm.

⭐ Repair is indicated for aneurysms > 5.5 cm in men, > 5.0 cm in women, or those with rapid growth (>0.5 cm in 6 months or >1 cm/year).

🔪 Management: Open Repair vs. EVAR

AAA management: Open vs. EVAR repair

FeatureOpen Surgical Repair (OSR)Endovascular Aneurysm Repair (EVAR)
ApproachMidline laparotomy, aortic cross-clamp, sutured graftPercutaneous femoral access, deployed stent-graft
MortalityHigher peri-op mortality (3-5%)Lower peri-op mortality (<1.5%)
RecoveryLonger hospital stay, ↑ painShorter hospital stay, ↓ pain
Late ComplicationAortoenteric fistula, graft infectionEndoleak, graft migration/fracture
Follow-upLess intensive surveillanceLifelong imaging surveillance required

⭐ > EVAR's primary long-term complication is endoleak: persistent blood flow into the aneurysm sac outside the stent-graft. Type II is most common (from lumbar/IMA back-bleeding) and often observed. Type I (inadequate seal) requires urgent intervention.

💥 Complications - The Aftermath

  • Early (<30d): MI (most common cause of death), AKI, colon ischemia (IMA ligation), graft thrombosis, limb ischemia.
  • Late (>30d): Aortoenteric fistula (herald bleed → massive GI bleed), graft infection (S. aureus), anastomotic pseudoaneurysm.
  • EVAR-Specific: Endoleak (persistent blood flow into aneurysm sac), graft migration.

⭐ Bowel ischemia classically presents with bloody diarrhea and abdominal pain post-op, often involving the sigmoid colon (watershed area of IMA).

Type II endoleak after EVAR: CT and angiographic views

⚡ Biggest Takeaways

  • Screening is a one-time ultrasound for men 65-75 who have ever smoked.
  • Repair is indicated for diameter >5.5 cm, rapid growth (>0.5 cm/6 mo), or symptoms.
  • The classic triad of rupture is hypotension, a pulsatile abdominal mass, and severe back/flank pain.
  • EVAR has lower perioperative mortality but requires surveillance for endoleaks.
  • Open repair risks include ischemic colitis (early) and aortoenteric fistula (late).
  • Myocardial infarction is the leading cause of death post-operatively.

Practice Questions: Abdominal aortic aneurysm repair

Test your understanding with these related questions

A 70-year-old man presents for his annual check-up. He says he feels well except for occasional abdominal pain. He describes the pain as 4/10–5/10 in intensity, diffusely localized to the periumbilical and epigastric regions, radiating to the groin. The pain occurs 1–2 times a month and always subsides on its own. The patient denies any recent history of fever, chills, nausea, vomiting, change in body weight, or change in bowel and/or bladder habits. His past medical history is significant for hypertension, hyperlipidemia, and peripheral vascular disease, managed with lisinopril and simvastatin. The patient reports a 40-pack-year smoking history and 1–2 alcoholic drinks a day. The blood pressure is 150/100 mm Hg and the pulse is 80/min. Peripheral pulses are 2+ bilaterally in all extremities. Abdominal exam reveals a bruit in the epigastric region along with mild tenderness to palpation with no rebound or guarding. There is also a pulsatile abdominal mass felt on deep palpation at the junction of the periumbilical and the suprapubic regions. The remainder of the physical exam is normal. Laboratory studies show: Serum total cholesterol 175 mg/dL Serum total bilirubin 1 mg/dL Serum amylase 25 U/L Serum alanine aminotransferase (ALT) 20 U/L Serum aspartate aminotransferase (AST) 16 U/L Which of the following is the most likely diagnosis in this patient?

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Flashcards: Abdominal aortic aneurysm repair

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EF < _____% and MI within _____ months are absolute contraindications to non-cardiac surgery

TAP TO REVEAL ANSWER

EF < _____% and MI within _____ months are absolute contraindications to non-cardiac surgery

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