Prostate surgery basics

Prostate surgery basics

Prostate surgery basics

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🗺️ Anatomy - The Surgical Landscape

  • Zonal Anatomy:
    • Peripheral Zone (PZ): ~70% of gland; site of most prostate cancers. Palpable on Digital Rectal Exam (DRE).
    • Transitional Zone (TZ): ~5% of gland; surrounds the urethra. Origin of Benign Prostatic Hyperplasia (BPH).
    • Central Zone (CZ): ~25%; surrounds the ejaculatory ducts.
  • Neurovascular Bundles (NVB):
    • Run posterolaterally to the prostate.
    • Contain cavernous nerves (from pelvic plexus) crucial for erectile function.
  • Critical Relations:
    • Posterior: Denonvilliers' fascia separates prostate from the rectum.
    • Apex: Near external urethral sphincter (key for continence).

Prostate MRI: Coronal & Axial Views with Anatomy

⭐ Injury to the cavernous nerves within the posterolateral neurovascular bundles during radical prostatectomy is the primary cause of post-operative erectile dysfunction.

🔪 Management - The Surgeon's Toolkit

  • Transurethral Resection of the Prostate (TURP):

    • Indication: Gold standard for moderate-to-severe BPH.
    • Procedure: Resects tissue from the transitional zone.
    • ⚠️ Complications: Retrograde ejaculation (most common), TURP syndrome.
  • Laser Enucleation (HoLEP/ThuLEP):

    • Indication: BPH, especially large glands (>80g).
    • Advantage: ↓ bleeding risk vs. TURP.
  • Radical Prostatectomy (RP):

    • Indication: Curative intent for localized prostate cancer.
    • ⚠️ Complications: Erectile dysfunction (cavernous nerve injury), urinary incontinence (sphincter damage).

TURP Syndrome: Life-threatening dilutional hyponatremia from absorption of hypotonic irrigation fluid (glycine, sorbitol). Presents with nausea, confusion, hypertension, bradycardia, and visual changes.

⚠️ Complications - Navigating the Risks

  • Immediate:

    • Bleeding: Most common early issue; monitor for clot retention.
    • TURP Syndrome: Hyponatremia from absorption of hypotonic irrigation fluid (glycine, sorbitol). Presents with confusion, nausea, HTN, bradycardia.
    • Infection: UTI, prostatitis.
  • Long-Term:

    • Erectile Dysfunction (ED): Damage to cavernous nerves in posterolateral neurovascular bundles. Nerve-sparing techniques are key.
    • Urinary Incontinence: Stress incontinence from external urethral sphincter injury.
    • Retrograde Ejaculation: Common after TURP; semen enters the bladder.
    • Bladder Neck Contracture / Urethral Stricture: Late fibrotic scarring causing obstruction.

TURP Syndrome is a medical emergency. The combination of hyponatremia, fluid overload, and potential glycine toxicity can lead to seizures and coma.

📋 Clinical - Post-Op Playbook

  • Catheter & Irrigation:
    • Indwelling Foley catheter is standard post-op.
    • Continuous Bladder Irrigation (CBI) post-TURP prevents clot retention. Titrate to keep urine pink.
  • Medications:
    • Analgesics for pain.
    • Anticholinergics (e.g., oxybutynin) for bladder spasms.
    • Stool softeners (e.g., docusate) to prevent straining.
  • Activity & Monitoring:
    • Avoid heavy lifting (>10 lbs) for 4-6 weeks.
    • ⚠️ Expect initial hematuria; report bright red blood or large clots.
    • Follow-up for catheter removal, pathology review, and PSA monitoring.

⭐ Retrograde ejaculation is the most common long-term complication following TURP.

⚡ High-Yield Points - Biggest Takeaways

  • Transurethral Resection of the Prostate (TURP) for BPH risks TURP syndrome (hyponatremia, fluid overload) and retrograde ejaculation.
  • Radical Prostatectomy for localized cancer risks erectile dysfunction (cavernous nerve injury) and stress urinary incontinence.
  • Nerve-sparing techniques during prostatectomy are critical for preserving post-operative erectile function.
  • Post-prostatectomy PSA should become undetectable; a rising PSA signals biochemical recurrence.
  • Stress incontinence after surgery is often due to internal urethral sphincter damage.
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Practice Questions: Prostate surgery basics

Test your understanding with these related questions

A 68-year-old man with hypertension comes to the physician because of fatigue and difficulty initiating urination. He wakes up several times a night to urinate. He does not take any medications. His blood pressure is 166/82 mm Hg. Digital rectal examination shows a firm, non-tender, and uniformly enlarged prostate. Which of the following is the most appropriate pharmacotherapy?

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Flashcards: Prostate surgery basics

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Benign prostatic hyperplasia may be treated with surgical resection, with the gold standard being the _____ procedure

TAP TO REVEAL ANSWER

Benign prostatic hyperplasia may be treated with surgical resection, with the gold standard being the _____ procedure

TURP

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