Surgical oncology emergencies

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💥 Pathophysiology - Anatomic Catastrophes

  • Obstruction: Tumor mass physically blocks a lumen.

    • GI Tract: Malignant Bowel Obstruction (MBO) from colorectal, ovarian CA.
    • Biliary Tree: Obstructive jaundice from pancreatic head CA, cholangiocarcinoma.
    • Urinary Tract: Hydronephrosis from cervical, prostate, bladder CA.
    • Airway: Stridor, dyspnea from lung, laryngeal, thyroid CA.
  • Perforation: Tumor necrosis or invasion through a hollow viscus wall.

    • Leads to peritonitis, sepsis.
    • Common in GI lymphomas, GISTs, advanced colorectal CA.
  • Hemorrhage: Tumor erosion into blood vessels or bleeding from friable tumor surface.

    • Presents as acute bleed (e.g., hemoptysis) or chronic anemia.

⭐ Ovarian cancer is a leading cause of malignant bowel obstruction from an extra-intestinal primary tumor, often causing diffuse peritoneal studding and multiple points of obstruction.

CT scan of malignant bowel obstruction

🚩 Clinical Manifestations - Red Flag Rundown

EmergencyKey Signs & SymptomsDiagnostic Clues
SVC SyndromeFacial/arm edema, plethora, JVD, dyspnea, cough, headache. 💡 Pemberton's sign (facial flushing on arm elevation).Chest X-ray: widened mediastinum. CT chest with contrast is definitive.
MSCC⚠️ New/worsening back pain (esp. nocturnal/supine), radicular pain, motor weakness, sensory loss, saddle anesthesia, bowel/bladder dysfunction.MRI of the entire spine is the gold standard.
MBONausea, vomiting (bilious/feculent), abdominal distention, obstipation, colicky pain. Bowel sounds: high-pitched → absent.Abdominal X-ray: dilated loops, air-fluid levels. CT abdomen confirms level/cause.

⏱️ Diagnosis - Race Against Time

  • Initial Steps: Rapid ABCs assessment, focused history (cancer type, prior treatments), and targeted physical exam (neurologic, vascular).
  • Core Labs: CBC, CMP, coagulation panel, lactate. Consider tumor markers if relevant.
  • Malignant Spinal Cord Compression (MSCC):
    • MRI of the entire spine is the gold standard.
  • Superior Vena Cava (SVC) Syndrome:
    • CT chest with IV contrast to visualize obstruction.
  • Malignant Bowel Obstruction (MBO):
    • Initial: Abdominal X-ray (air-fluid levels).
    • Definitive: CT abdomen/pelvis with contrast.
  • Tumor Hemorrhage:
    • Endoscopy, bronchoscopy, or angiography for localization.

Epidural metastasis grading on axial CT and MRI

⭐ New-onset back pain in a known cancer patient, especially with neurologic symptoms (weakness, sensory loss, incontinence), is Malignant Spinal Cord Compression until proven otherwise.

⚔️ Management - Damage Control

A staged surgical strategy for exsanguinating patients (e.g., ruptured tumor), prioritizing physiology over immediate definitive repair. The goal is to interrupt the "Lethal Triad."

  • Phase 1 Techniques:
    • Hemorrhage: Perihepatic packing, vessel ligation/shunting.
    • Contamination: Resection without anastomosis (staple off bowel).
  • Phase 2 Goal: Restore physiologic reserve.
  • Phase 3 Goal: Definitive anatomical repair and formal closure.

⭐ The "Lethal Triad" - Hypothermia (<35°C), Acidosis (pH <7.2), and Coagulopathy - is the primary indication. Each component potentiates the others, creating a vicious cycle that must be broken in the ICU.

⚡ Biggest Takeaways

  • Spinal cord compression: Suspect in cancer patients with new back pain/neuro deficits. Get emergent MRI and give high-dose corticosteroids.
  • SVC syndrome: Most often from lung cancer/lymphoma. Presents with facial/arm swelling. Treat with radiation and/or stenting.
  • Malignant pericardial effusion/tamponade: Diagnose with echocardiogram; treat emergently with pericardiocentesis.
  • Malignant bowel obstruction: Manage with NG tube decompression and consider surgical bypass or stenting.
  • Acute airway obstruction: Requires emergent tracheostomy or endobronchial stenting/debulking.
  • Massive tumor bleeding (e.g., hemoptysis): Control with angiographic embolization or surgery.

Practice Questions: Surgical oncology emergencies

Test your understanding with these related questions

A 60-year-old patient presents to the urgent care clinic with complaints of pain and abdominal distention for the past several weeks. The pain began with a change in bowel habits 3 months ago, and he gradually defecated less until he became completely constipated, which led to increasing pain and distention. He also mentions that he has lost weight during this period, even though he has not changed his diet. When asked about his family history, the patient reveals that his brother was diagnosed with colorectal cancer at 65 years of age. An abdominal radiograph and CT scan were done which confirmed the diagnosis of obstruction. Which of the following locations in the digestive tract are most likely involved in this patient’s disease process?

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Flashcards: Surgical oncology emergencies

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EF < _____% and MI within _____ months are absolute contraindications to non-cardiac surgery

TAP TO REVEAL ANSWER

EF < _____% and MI within _____ months are absolute contraindications to non-cardiac surgery

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