Non-operative management principles US Medical PG Practice Questions and MCQs
Practice US Medical PG questions for Non-operative management principles. These multiple choice questions (MCQs) cover important concepts and help you prepare for your exams.
Non-operative management principles US Medical PG Question 1: A 62-year-old man presents to the emergency department with acute pain in the left lower abdomen and profuse rectal bleeding. These symptoms started 3 hours ago. The patient has chronic constipation and bloating, for which he takes lactulose. His family history is negative for gastrointestinal disorders. His temperature is 38.2°C (100.8°F), blood pressure is 90/60 mm Hg, and pulse is 110/min. On physical examination, the patient appears drowsy, and there is tenderness with guarding in the left lower abdominal quadrant. Flexible sigmoidoscopy shows multiple, scattered diverticula with acute mucosal inflammation in the sigmoid colon. Which of the following is the best initial treatment for this patient?
- A. Elective colectomy
- B. Dietary modification and antibiotics
- C. Volume replacement, analgesia, intravenous antibiotics, and endoscopic hemostasis
- D. Volume replacement, analgesia, intravenous antibiotics, and surgical hemostasis (Correct Answer)
- E. Reassurance and no treatment is required
Non-operative management principles Explanation: ***Volume replacement, analgesia, intravenous antibiotics, and surgical hemostasis***
- This patient presents with **acute complicated diverticulitis** with signs of **peritonitis** (left lower abdominal pain with guarding) and **septic shock** (fever 38.2°C, hypotension 90/60 mm Hg, tachycardia 110/min, drowsiness).
- Initial management requires **volume replacement** to address hypovolemia and shock, **analgesia** for pain control, and **broad-spectrum intravenous antibiotics** covering gram-negative and anaerobic organisms.
- The presence of **peritonitis with hemodynamic instability** indicates complicated diverticulitis requiring **surgical intervention** (typically sigmoid resection with colostomy - Hartmann procedure) after initial resuscitation.
- While the patient has rectal bleeding, the dominant clinical picture is **perforation/transmural inflammation** requiring surgery, not just bleeding control.
*Volume replacement, analgesia, intravenous antibiotics, and endoscopic hemostasis*
- **Endoscopic hemostasis** is appropriate for uncomplicated diverticular bleeding without signs of perforation or peritonitis.
- In this case, the patient has **guarding** (indicating peritonitis) and **septic shock**, suggesting transmural inflammation or perforation that cannot be managed endoscopically.
- Endoscopy is relatively contraindicated in acute diverticulitis with peritonitis due to risk of worsening perforation.
*Elective colectomy*
- While colectomy is the correct surgical approach, the term **"elective"** is inappropriate for this acute, life-threatening emergency.
- This patient requires **urgent/emergency surgery** after initial resuscitation, not scheduled elective surgery.
*Dietary modification and antibiotics*
- **Dietary modification** (high-fiber diet) is a preventive strategy for uncomplicated diverticular disease, not treatment for acute complicated diverticulitis.
- While antibiotics are necessary, this option fails to address the **septic shock, hypovolemia, and need for surgical intervention** in complicated diverticulitis with peritonitis.
*Reassurance and no treatment is required*
- The patient exhibits **life-threatening complications**: septic shock, peritonitis, and hemodynamic instability.
- **No treatment** would result in rapid deterioration, multi-organ failure, and death.
Non-operative management principles US Medical PG Question 2: A 65-year-old patient presents with acute left lower quadrant abdominal pain and is diagnosed with diverticulitis. Which of the following is most likely to have prevented this patient's condition?
- A. Anticoagulation with warfarin
- B. High-fiber diet (Correct Answer)
- C. Different antibiotic regimen for bronchitis
- D. Sitz baths and nifedipine suppositories
- E. Long-term use of aspirin
Non-operative management principles Explanation: ***High-fiber diet***
- A **high-fiber diet** increases stool bulk and reduces intracolonic pressure, thereby preventing the formation of **diverticula** and reducing the risk of diverticulitis.
- It helps maintain **regular bowel movements** and minimizes straining, which are key in preventing diverticular disease.
*Anticoagulation with warfarin*
- **Warfarin** is an anticoagulant used to prevent blood clots; it has no direct impact on the formation of **diverticula** or the prevention of diverticulitis.
- While bleeding is a potential complication of diverticular disease, anticoagulation would generally *increase* the risk of bleeding, not prevent the condition itself.
*Different antibiotic regimen for bronchitis*
- Antibiotics treat **bacterial infections** and are irrelevant in the prevention of diverticulitis, which primarily relates to dietary and colonic pressure issues.
- Changing an antibiotic regimen for an unrelated respiratory infection like bronchitis would not affect the risk factors for **diverticular disease**.
*Sitz baths and nifedipine suppositories*
- **Sitz baths** and **nifedipine suppositories** are treatments for anorectal conditions like **hemorrhoids** or **anal fissures** and do not influence the development of diverticulitis.
- These interventions target symptoms in the anal region and have no physiological connection to the colon's diverticular disease processes.
*Long-term use of aspirin*
- **Aspirin** is an anti-inflammatory and antiplatelet agent used for pain relief and cardiovascular protection; it does not prevent the formation of **diverticula** or diverticulitis.
- Non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin can actually **increase the risk of diverticular complications**, such as bleeding or perforation, rather than prevent the disease.
Non-operative management principles US Medical PG Question 3: A 6-month-old male presents to the emergency department with his parents after his three-year-old brother hit him on the arm with a toy truck. His parents are concerned that the minor trauma caused an unusual amount of bruising. The patient has otherwise been developing well and meeting all his milestones. His parents report that he sleeps throughout the night and has just started to experiment with solid food. The patient’s older brother is in good health, but the patient’s mother reports that some members of her family have an unknown blood disorder. On physical exam, the patient is agitated and difficult to soothe. He has 2-3 inches of ecchymoses and swelling on the lateral aspect of the left forearm. The patient has a neurological exam within normal limits and pale skin with blue irises. An ophthalmologic evaluation is deferred.
Which of the following is the best initial step?
- A. Genetic testing
- B. Complete blood count and coagulation panel (Correct Answer)
- C. Ensure the child's safety and alert the police
- D. Peripheral blood smear
- E. Hemoglobin electrophoresis
Non-operative management principles Explanation: ***Complete blood count and coagulation panel***
- The unusual amount of **bruising** after minor trauma, along with a family history of an unknown blood disorder, strongly suggests a potential **bleeding disorder**. A **CBC** and a **coagulation panel** (PT, aPTT, fibrinogen) are essential initial steps to evaluate for abnormalities in platelets, clotting factors, or other hematologic conditions.
- These tests can help narrow down the differential diagnosis between **platelet dysfunction**, **coagulopathies** (like hemophilia or von Willebrand disease), or other less common bleeding disorders, guiding further specific investigations.
- **Important consideration:** The presence of **blue sclera** (described as "blue irises") raises concern for **osteogenesis imperfecta (OI)**, a connective tissue disorder causing bone fragility. However, initial hematologic screening is still appropriate given the family history of blood disorder and presentation of excessive bruising. If coagulation studies are normal, imaging and further workup for OI would be indicated.
*Genetic testing*
- While a genetic component is plausible given the patient's family history and clinical presentation (blue sclera may suggest osteogenesis imperfecta), **genetic testing** is typically performed *after* initial laboratory workup has identified a specific type of bleeding or inherited disorder.
- Starting with genetic testing without basic hematologic parameters is not the most efficient or cost-effective initial diagnostic approach.
*Ensure the child's safety and alert the police*
- While child abuse should always be considered in cases of unexplained or excessive bruising, the presence of a **family history of a blood disorder** and the **blue sclera** (suggesting possible osteogenesis imperfecta) make **medical causes** more immediate concerns for initial investigation.
- Pursuing a medical workup first often clarifies whether abuse is the primary explanation, although child protective services should be notified if suspicion remains high after medical evaluation.
*Peripheral blood smear*
- A **peripheral blood smear** provides information on red blood cell morphology, platelet size and number, and white blood cell differential. While useful in assessing for some hematologic conditions, it is often performed *after* a CBC has indicated abnormalities or in conjunction with specialized testing.
- It would not be the *best initial step* as it doesn't directly assess clotting factor function, which is critical in evaluating significant bruising severity.
*Hemoglobin electrophoresis*
- **Hemoglobin electrophoresis** is used to diagnose **hemoglobinopathies** like sickle cell anemia or thalassemia.
- The patient's symptoms (easy bruising) are not characteristic of hemoglobinopathies, and while he has pale skin, this test would not be the initial step to investigate a bleeding disorder.
Non-operative management principles US Medical PG Question 4: An epidemiologist is evaluating the efficacy of Noxbinle in preventing HCC deaths at the population level. A clinical trial shows that over 5 years, the mortality rate from HCC was 25% in the control group and 15% in patients treated with Noxbinle 100 mg daily. Based on this data, how many patients need to be treated with Noxbinle 100 mg to prevent, on average, one death from HCC?
- A. 20
- B. 73
- C. 10 (Correct Answer)
- D. 50
- E. 100
Non-operative management principles Explanation: ***10***
- The **number needed to treat (NNT)** is calculated by first finding the **absolute risk reduction (ARR)**.
- **ARR** = Risk in control group - Risk in treatment group = 25% - 15% = **10%** (or 0.10).
- **NNT = 1 / ARR** = 1 / 0.10 = **10 patients**.
- This means that **10 patients must be treated with Noxbinle to prevent one death from HCC** over 5 years.
*20*
- This would result from an ARR of 5% (1/0.05 = 20), which is not supported by the data.
- May arise from miscalculating the risk difference or incorrectly halving the actual ARR.
*73*
- This value does not correspond to any standard calculation of NNT from the given mortality rates.
- May result from confusion with other epidemiological measures or calculation error.
*50*
- This would correspond to an ARR of 2% (1/0.02 = 50), which significantly underestimates the actual risk reduction.
- Could result from incorrectly calculating the difference as a proportion rather than absolute percentage points.
*100*
- This would correspond to an ARR of 1% (1/0.01 = 100), grossly underestimating the treatment benefit.
- May result from confusing ARR with relative risk reduction or other calculation errors.
Non-operative management principles US Medical PG Question 5: A 24-year-old woman is brought to the emergency department after being assaulted. The paramedics report that the patient was found conscious and reported being kicked many times in the torso. She is alert and able to respond to questions. She denies any head trauma. She has a past medical history of endometriosis and a tubo-ovarian abscess that was removed surgically two years ago. Her only home medication is oral contraceptive pills. Her temperature is 98.5°F (36.9°C), blood pressure is 82/51 mmHg, pulse is 136/min, respirations are 24/min, and SpO2 is 94%. She has superficial lacerations to the face and severe bruising over her chest and abdomen. Her lungs are clear to auscultation bilaterally and her abdomen is soft, distended, and diffusely tender to palpation. Her skin is cool and clammy. Her FAST exam reveals fluid in the perisplenic space.
Which of the following is the next best step in management?
- A. Emergency laparotomy (Correct Answer)
- B. Abdominal radiograph
- C. Abdominal CT
- D. Fluid resuscitation
- E. Diagnostic peritoneal lavage
Non-operative management principles Explanation: ***Emergency laparotomy***
- The patient presents with **hemodynamic instability** (BP 82/51 mmHg, HR 136/min) and a **positive FAST exam** showing fluid in the perisplenic space, indicating intra-abdominal hemorrhage.
- According to **ATLS guidelines**, a hemodynamically unstable patient with a positive FAST exam requires **immediate operative intervention** to control bleeding. This is the definitive management for ongoing hemorrhage.
- While fluid resuscitation is initiated simultaneously (en route to OR), **surgical control of the bleeding source** is the priority and should not be delayed.
*Fluid resuscitation*
- Fluid resuscitation with IV crystalloids is essential and should be started immediately in this patient with hypovolemic shock.
- However, in a patient with **uncontrolled intra-abdominal hemorrhage** (positive FAST, hemodynamic instability), fluids alone will not stop the bleeding. Continued fluid resuscitation without surgical intervention can lead to dilutional coagulopathy and worsening outcomes.
- Fluid resuscitation occurs **concurrently with preparation for surgery**, not as a separate step that delays definitive management.
*Diagnostic peritoneal lavage*
- DPL is an invasive diagnostic procedure that has largely been replaced by FAST exam in modern trauma care.
- Given that the **FAST is already positive**, DPL would provide no additional useful information and would only **delay definitive surgical management**.
- In hemodynamically unstable patients with positive FAST, proceeding directly to laparotomy is indicated.
*Abdominal radiograph*
- Plain radiographs have **limited sensitivity** for detecting intra-abdominal bleeding or solid organ injury.
- They may show free air (indicating hollow viscus perforation) but cannot assess for fluid or characterize solid organ injuries.
- This would **delay necessary operative intervention** without providing actionable information.
*Abdominal CT*
- CT abdomen is the imaging modality of choice for **hemodynamically stable** trauma patients to characterize injuries and guide management.
- For **unstable patients**, CT is **contraindicated** as it delays definitive treatment and removes the patient from a resuscitation environment where deterioration can be immediately addressed.
Non-operative management principles US Medical PG Question 6: A 28-year-old male presents to his primary care physician with complaints of intermittent abdominal pain and alternating bouts of constipation and diarrhea. His medical chart is not significant for any past medical problems or prior surgeries. He is not prescribed any current medications. Which of the following questions would be the most useful next question in eliciting further history from this patient?
- A. "Does the diarrhea typically precede the constipation, or vice-versa?"
- B. "Is the diarrhea foul-smelling?"
- C. "Please rate your abdominal pain on a scale of 1-10, with 10 being the worst pain of your life"
- D. "Are the symptoms worse in the morning or at night?"
- E. "Can you tell me more about the symptoms you have been experiencing?" (Correct Answer)
Non-operative management principles Explanation: ***Can you tell me more about the symptoms you have been experiencing?***
- This **open-ended question** encourages the patient to provide a **comprehensive narrative** of their symptoms, including details about onset, frequency, duration, alleviating/aggravating factors, and associated symptoms, which is crucial for diagnosis.
- In a patient presenting with vague, intermittent symptoms like alternating constipation and diarrhea, allowing them to elaborate freely can reveal important clues that might not be captured by more targeted questions.
*Does the diarrhea typically precede the constipation, or vice-versa?*
- While knowing the sequence of symptoms can be helpful in understanding the **pattern of bowel dysfunction**, it is a very specific question that might overlook other important aspects of the patient's experience.
- It prematurely narrows the focus without first obtaining a broad understanding of the patient's overall symptomatic picture.
*Is the diarrhea foul-smelling?*
- Foul-smelling diarrhea can indicate **malabsorption** or **bacterial overgrowth**, which are important to consider in some gastrointestinal conditions.
- However, this is a **specific symptom inquiry** that should follow a more general exploration of the patient's symptoms, as it may not be relevant if other crucial details are missed.
*Please rate your abdominal pain on a scale of 1-10, with 10 being the worst pain of your life*
- Quantifying pain intensity is useful for assessing the **severity of discomfort** and monitoring changes over time.
- However, for a patient with intermittent rather than acute, severe pain, understanding the **character, location, and triggers** of the pain is often more diagnostically valuable than just a numerical rating initially.
*Are the symptoms worse in the morning or at night?*
- Diurnal variation can be relevant in certain conditions, such as inflammatory bowel diseases where nocturnal symptoms might be more concerning, or functional disorders whose symptoms might be stress-related.
- This is another **specific question** that should come after gathering a more complete initial picture of the patient's symptoms to ensure no key information is overlooked.
Non-operative management principles US Medical PG Question 7: A 27-year-old man is brought to the emergency department by emergency medical services. The patient was an unrestrained passenger in a head-on collision that occurred 15 minutes ago and is currently unresponsive. His temperature is 99.5°F (37.5°C), blood pressure is 60/33 mmHg, pulse is 180/min, respirations are 17/min, and oxygen saturation is 95% on room air. A FAST exam demonstrates fluid in Morrison’s pouch. Laboratory values are drawn upon presentation to the ED and sent off. The patient is started on IV fluids and an initial trauma survey is started. Twenty minutes later, his blood pressure is 95/65 mmHg, and his pulse is 110/min. The patient is further stabilized and is scheduled for emergency surgery. Which of the following best represents this patient’s most likely initial laboratory values?
- A. Hemoglobin: 10 g/dL, Hematocrit: 30%, MCV: 110 µm^3
- B. Hemoglobin: 19 g/dL, Hematocrit: 55%, MCV: 95 µm^3
- C. Hemoglobin: 7 g/dL, Hematocrit: 21%, MCV: 75 µm^3
- D. Hemoglobin: 11 g/dL, Hematocrit: 33%, MCV: 88 µm^3 (Correct Answer)
- E. Hemoglobin: 15 g/dL, Hematocrit: 45%, MCV: 90 µm^3
Non-operative management principles Explanation: ***Hemoglobin: 11 g/dL, Hematocrit: 33%, MCV: 88 µm^3***
- The patient experienced significant trauma and is experiencing **hemorrhagic shock**, as evidenced by his initial **hypotension** (BP 60/33 mmHg), **tachycardia** (pulse 180/min), and positive **FAST exam** for fluid in Morrison's pouch, indicating intra-abdominal bleeding.
- The initial hemoglobin and hematocrit could be mildly decreased due to acute blood loss, but significant drops are often *not immediately apparent* as plasma volume has not yet moved into the intravascular compartment to dilute the remaining red blood cells. A hemoglobin of 11 g/dL and hematocrit of 33% are consistent with **acute blood loss** before significant hemodilution occurs. MCV of 88 µm^3 is within the normal range for **normocytic anemia** seen in acute hemorrhage.
*Hemoglobin: 10 g/dL, Hematocrit: 30%, MCV: 110 µm^3*
- While a hemoglobin of 10 g/dL and hematocrit of 30% are consistent with anemia due to blood loss, an **MCV of 110 µm^3** (macrocytic) is not typically seen in acute hemorrhage.
- Macrocytic anemia usually results from conditions like **B12 or folate deficiency**, alcoholism, or liver disease, which are not suggested by the acute traumatic scenario.
*Hemoglobin: 19 g/dL, Hematocrit: 55%, MCV: 95 µm^3*
- This indicates **polycythemia** (abnormally high red blood cell count), which is the opposite of what would be expected in a patient experiencing acute hemorrhagic shock.
- These values would suggest conditions like **polycythemia vera** or severe dehydration, which are not relevant in this acute trauma setting.
*Hemoglobin: 7 g/dL, Hematocrit: 21%, MCV: 75 µm^3*
- While a hemoglobin of 7 g/dL and hematocrit of 21% represent significant anemia consistent with major blood loss, these values are typically seen *later* as **hemodilution** occurs, or in cases of chronic blood loss.
- An **MCV of 75 µm^3** (microcytic) is generally indicative of **iron deficiency anemia** or thalassemia, which develops over time and is not characteristic of acute traumatic blood loss.
*Hemoglobin: 15 g/dL, Hematocrit: 45%, MCV: 90 µm^3*
- These values are within the **normal range** for hemoglobin and hematocrit, which would not be expected in a patient presenting with signs of **hemorrhagic shock** and a positive FAST exam indicating significant internal bleeding.
- This would suggest either very minor blood loss or that the values were taken before any bleeding had occurred or before hemodilution had a chance to manifest.
Non-operative management principles US Medical PG Question 8: A 79-year-old man presents to the emergency department with abdominal pain. The patient describes the pain as severe, tearing, and radiating to the back. His history is significant for hypertension, hyperlipidemia, intermittent claudication, and a 60 pack-year history of smoking. He also has a previously diagnosed stable abdominal aortic aneurysm followed by ultrasound screening. On exam, the patient's temperature is 98°F (36.7°C), pulse is 113/min, blood pressure is 84/46 mmHg, respirations are 24/min, and oxygen saturation is 99% on room air. The patient is pale and diaphoretic, and becomes confused as you examine him. Which of the following is most appropriate in the evaluation and treatment of this patient?
- A. Abdominal ultrasound
- B. Abdominal CT with contrast
- C. Surgery (Correct Answer)
- D. Abdominal MRI
- E. Abdominal CT without contrast
Non-operative management principles Explanation: ***Surgery***
- The patient presents with classic signs of a **ruptured abdominal aortic aneurysm (AAA)**, including sudden, severe, tearing abdominal pain radiating to the back, and signs of **hypovolemic shock** (hypotension, tachycardia, pallor, diaphoresis, confusion). Immediate surgical intervention is life-saving.
- Given the patient's **hemodynamic instability** and strong clinical suspicion for AAA rupture, delaying treatment for imaging studies is inappropriate and would significantly worsen the prognosis.
*Abdominal ultrasound*
- While ultrasound can detect an AAA, it is **less effective in identifying rupture**, especially retroperitoneal hemorrhage, and in hemodynamically unstable patients, the time spent on imaging is time lost for definitive treatment.
- The patient's critical condition warrants immediate intervention, and ultrasound would not provide enough detail or be fast enough to guide surgical planning in an emergency.
*Abdominal CT with contrast*
- CT angiography is the **gold standard for diagnosing AAA rupture** in stable patients, as it can visualize the aneurysm, rupture site, and extent of hemorrhage.
- However, for a **hemodynamically unstable patient** with a high clinical suspicion of rupture, taking the patient to CT risks further deterioration and delays life-saving surgery.
*Abdominal MRI*
- MRI is **contraindicated in unstable patients** due to the time required for imaging and the logistical challenges of monitoring critically ill patients in the MRI suite.
- It also provides no additional benefit over CT in an acute rupture setting and is generally not used for emergency AAA rupture diagnosis.
*Abdominal CT without contrast*
- A non-contrast CT might show the aneurysm and some signs of hemorrhage, but it would provide **less diagnostic information** regarding the rupture site and relationship to surrounding structures compared to a contrast-enhanced study.
- Like other imaging modalities, it still represents a **critical delay** for a patient in hypovolemic shock from a ruptured AAA, for whom immediate surgical intervention is paramount.
Non-operative management principles US Medical PG Question 9: A 67-year-old woman has fallen from the second story level of her home while hanging laundry. She was brought to the emergency department immediately and presented with severe abdominal pain. The patient is anxious, and her hands and feet feel very cold to the touch. There is no evidence of bone fractures, superficial skin wounds, or a foreign body penetration. Her blood pressure is 102/67 mm Hg, respirations are 19/min, pulse is 87/min, and temperature is 36.7°C (98.0°F). Her abdominal exam reveals rigidity and severe tenderness. A Foley catheter and nasogastric tube are inserted. The central venous pressure (CVP) is 5 cm H2O. The medical history is significant for hypertension. Which of the following is best indicated for the evaluation of this patient?
- A. X-Ray
- B. Ultrasound
- C. Peritoneal lavage
- D. CT scan (Correct Answer)
- E. Diagnostic laparotomy
Non-operative management principles Explanation: ***CT scan***
- A **CT scan of the abdomen and pelvis** is the most indicated imaging modality for evaluating blunt abdominal trauma due to its high sensitivity and specificity in detecting solid organ injuries, free fluid, and active bleeding.
- Given the patient's severe abdominal pain, rigidity, and tenderness after a significant fall, a CT scan will provide detailed anatomical information crucial for guiding further management.
*X-Ray*
- An **X-ray** is useful for detecting bone fractures, but it has limited utility in assessing soft tissue and organ injuries within the abdomen.
- It would not effectively visualize internal bleeding or organ damage, which are primary concerns in this patient given the mechanism of injury and symptoms.
*Ultrasound*
- An **ultrasound (FAST exam)** is effective for rapid detection of free fluid in the abdomen (indicating bleeding or fluid leakage) and can be done at the bedside.
- However, it is operator-dependent and less sensitive than CT for identifying specific organ injuries, retroperitoneal hematomas, or the source of bleeding.
*Peritoneal lavage*
- **Diagnostic peritoneal lavage (DPL)** is an invasive procedure primarily used to detect intra-abdominal bleeding in hemodynamically unstable patients, but it has largely been replaced by ultrasound and CT in stable patients.
- While it can detect blood, it is less specific for identifying the source of bleeding and does not provide anatomical detail, and carries risks of complications like bowel perforation.
*Diagnostic laparotomy*
- **Diagnostic laparotomy** is a surgical procedure to directly visualize abdominal contents and is indicated in cases of clear signs of peritonitis, hemodynamic instability with confirmed intra-abdominal bleeding, or evisceration.
- It is an invasive intervention and would not be the initial diagnostic step in a hemodynamically stable patient without clear indication for immediate surgery.
Non-operative management principles US Medical PG Question 10: A 51-year-old man with a recent diagnosis of peptic ulcer disease currently treated with an oral proton pump inhibitor twice daily presents to the urgent care center complaining of acute abdominal pain which began suddenly less than 2 hours ago. On physical exam, you find his abdomen to be mildly distended, diffusely tender to palpation, and positive for rebound tenderness. Given the following options, what is the next best step in patient management?
- A. Serum gastrin level
- B. Urgent CT abdomen and pelvis (Correct Answer)
- C. H. pylori testing
- D. Abdominal radiographs
- E. Upper endoscopy
Non-operative management principles Explanation: ***Urgent CT abdomen and pelvis***
- The sudden onset of severe abdominal pain, diffuse tenderness, and **rebound tenderness** in a patient with a history of peptic ulcer disease (PUD) suggests a **perforated ulcer**, which is a surgical emergency.
- A CT scan is the **most sensitive imaging modality** for detecting **free air** (pneumoperitoneum) and can confirm the diagnosis with >95% sensitivity, helping to localize the perforation and identify complications such as abscess formation.
- CT also helps evaluate alternative diagnoses in the acute abdomen and provides detailed anatomic information for surgical planning.
*Serum gastrin level*
- This test is primarily used in the diagnosis of **Zollinger-Ellison syndrome**, a rare condition characterized by gastrinomas leading to severe, refractory PUD.
- It is not indicated in an acute emergency setting with signs of perforation, as it would delay critical diagnostic imaging and management.
*H. pylori testing*
- **_H. pylori_ infection** is a common cause of PUD, but testing for it is part of routine initial management or follow-up for chronic disease.
- Testing would not address the immediate life-threatening complication of suspected perforation and would delay definitive diagnosis.
*Abdominal radiographs*
- An upright chest X-ray or abdominal radiograph can detect **free air under the diaphragm** in cases of perforation and is a reasonable initial imaging test.
- However, plain radiographs have lower sensitivity (75-80%) compared to CT scan and may miss smaller perforations or provide insufficient information about the location and extent of injury.
- In modern practice with readily available CT, cross-sectional imaging is preferred for its superior diagnostic accuracy in evaluating the acute abdomen.
*Upper endoscopy*
- **Upper endoscopy** is a valuable diagnostic and therapeutic tool for stable PUD but is **absolutely contraindicated** in cases of suspected or confirmed hollow viscus perforation.
- Introducing an endoscope with air insufflation could worsen the perforation and lead to further contamination of the peritoneal cavity, increasing morbidity and mortality.
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