Large bowel obstruction

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Etiology & Pathophysiology - The Big Blockage

  • Primary Causes (in order of frequency):

    • Colorectal Cancer (CRC): Most common cause (~60%), typically in the sigmoid colon.
    • Diverticular Disease: Strictures from chronic inflammation.
    • Volvulus: Twisting of the bowel, usually sigmoid or cecal.
    • Less common: Adhesions (more for SBO), hernias, fecal impaction.
  • Pathophysiology Cascade:

    • Obstruction → proximal bowel distention with gas & fluid.
    • ↑ Intraluminal pressure → impaired capillary perfusion → bowel wall ischemia.
    • Closed-loop obstruction (if ileocecal valve is competent) → rapid pressure ↑ → risk of perforation.

Abdominal X-ray: Large bowel obstruction with dilated colon

Exam Favorite: The most common cause of large bowel obstruction in the adult population is adenocarcinoma of the colon.

Clinical Presentation - Signs of the Siege

  • Cardinal Features:

    • Abdominal Distension: Pronounced, tympanitic percussion.
    • Colicky Abdominal Pain: Infra-umbilical, progressing from intermittent to constant.
    • Obstipation: Absolute failure to pass feces or flatus is a hallmark.
    • Nausea & Vomiting: Often a late finding, may be feculent.
  • Physical Examination:

    • High-pitched, metallic tinkling bowel sounds → progressing to a silent abdomen.
    • Empty rectal vault on digital rectal exam (DRE).
    • ⚠️ Peritoneal signs (rebound tenderness, guarding) imply ischemia or perforation.

Abdominal X-ray: Large Bowel Obstruction with Anastomosis

Law of Laplace & Perforation Risk: With a competent ileocecal valve (a closed loop), the cecum, having the largest diameter, endures the highest wall tension ($T = P \times r$). A cecal diameter > 12 cm on imaging signals impending perforation.

Diagnostic Workup - Imaging the Impasse

Initial imaging starts with an Abdominal X-ray (AXR), though CT is the gold standard for confirmation and detailed assessment.

  • Abdominal X-ray (AXR):

    • Shows dilated large bowel (>6 cm in the colon, >9 cm in the cecum).
    • ⚠️ Cecal diameter >12 cm indicates impending perforation (Law of Laplace).
    • May show air-fluid levels, but less prominent than in SBO.
  • CT Scan (Abdomen/Pelvis with contrast):

    • Confirms diagnosis: Identifies transition point with proximal dilation and distal collapse.
    • Determines etiology: Pinpoints the cause (e.g., tumor, volvulus, stricture).
    • Assesses for complications: Detects ischemia, perforation, or abscess formation.

CT is crucial for differentiating true mechanical obstruction from pseudo-obstruction (Ogilvie syndrome), which shows diffuse colonic dilation without a discrete transition point.

Management - Breaking the Barricade

  • Initial Resuscitation & Stabilization:

    • NPO (Nil Per Os), aggressive IV fluid resuscitation.
    • Nasogastric (NG) tube for proximal decompression.
    • Broad-spectrum IV antibiotics (cover gram-negatives & anaerobes).
    • Correct electrolyte abnormalities.
  • Etiology-Specific Intervention:

⭐ Following endoscopic detorsion of a sigmoid volvulus, a rectal tube is often left in place to prevent recurrence prior to elective surgery.

High‑Yield Points - ⚡ Biggest Takeaways

  • The most common cause of LBO is colorectal cancer, followed by volvulus and diverticular stricture.
  • Key symptoms include gradual onset of abdominal distension and constipation; vomiting is a late feature.
  • Abdominal X-ray is the first-line imaging, but a CT scan is definitive for locating the cause.
  • Sigmoid volvulus has a characteristic "coffee bean" sign on X-ray; treat with endoscopic detorsion.
  • Cecal volvulus shows a "kidney bean" sign and usually requires emergent surgery.
  • Risk of ischemia and perforation necessitates urgent management, starting with supportive care and followed by surgery.

Practice Questions: Large bowel obstruction

Test your understanding with these related questions

A 70-year-old man comes to the clinic for generalized fatigue. He says that he is more tired than before and has difficulty catching his breath while walking upstairs. He feels tired quickly doing his usual activity such as gardening and shopping. He does not have any symptoms of fever, change in bowel habits, abdominal pain, rectal bleeding, or weight loss. His appetite is normal. His last colonoscopy was done 10 years ago and it was normal. His blood pressure is 116/74 and heart rate is 87/min. On physical examination, his conjunctivae are pale. A routine blood test shows iron deficiency anemia with hemoglobin of 10 gm/dL. His stool is positive for occult blood. He is then sent for a colonoscopy (image is shown). What is the most likely diagnosis for the above condition?

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Flashcards: Large bowel obstruction

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_____ may present as a palpable, pulsatile abdominal mass that grows with time

TAP TO REVEAL ANSWER

_____ may present as a palpable, pulsatile abdominal mass that grows with time

Abdominal aortic aneurysm

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