Gastrointestinal perforation

Gastrointestinal perforation

Gastrointestinal perforation

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Etiology & Pathophysiology - The Breach

  • Common Causes:

    • Peptic Ulcer Disease (PUD): Most frequent, esp. anterior duodenal ulcers.
    • Diverticulitis: Particularly sigmoid colon.
    • Appendicitis: Rupture leading to peritonitis.
    • Malignancy: Gastric or colorectal tumors eroding the wall.
    • Trauma: Blunt or penetrating injuries.
    • Iatrogenic: Post-procedural (e.g., colonoscopy, ERCP) or surgical.
    • Bowel Obstruction: Ischemic necrosis or cecal blowout.
    • Inflammatory Bowel Disease (IBD): Crohn's (transmural), toxic megacolon (UC).
  • Pathophysiology Cascade:

    • Breach of GI wall → Leakage of luminal contents (air, bacteria, enzymes, feces).
    • Chemical peritonitis → Bacterial peritonitis → Systemic inflammation (SIRS).
    • Fluid shift to peritoneum ("third spacing") → Hypovolemia & septic shock.

Anatomy of the Abdomen and Gastrointestinal Tract

⭐ The most common cause of pneumoperitoneum is a perforated duodenal ulcer. Free air under the diaphragm on an upright chest X-ray is the classic sign.

Clinical Presentation & Diagnosis - The Alarm Bells

  • History & Symptoms:
    • Sudden, severe, diffuse abdominal pain (“thunderclap” onset).
    • Syncope can occur due to profound vagal response.
    • Referred shoulder pain (Kehr's sign) from diaphragmatic irritation.
  • Physical Exam Findings:
    • Signs of peritonitis: guarding, rigidity, rebound tenderness.
    • Classic "board-like" abdomen is pathognomonic.
    • Systemic signs: Tachycardia, hypotension, fever (SIRS).

⭐ On exam, diminished liver dullness to percussion can be an early clue to pneumoperitoneum before imaging is even done.

Upright chest X-ray: Pneumoperitoneum with free air

Management - The Fix-It Crew

Immediate resuscitation is key. The approach follows a structured algorithm, often leading to surgical intervention.

  • Initial Stabilization (The ABCs):

    • NPO (Nil Per Os) & Nasogastric (NG) tube for gastric decompression.
    • Aggressive IV fluid resuscitation (crystalloids).
    • Broad-spectrum IV antibiotics (e.g., Piperacillin-Tazobactam) to cover gram-negatives and anaerobes.
    • Insert a Foley catheter to monitor urine output.
  • Definitive Treatment:

    • The primary goal is source control (closing the perforation) and peritoneal lavage.

⭐ For a perforated peptic ulcer, an omental patch repair (Graham patch) is a common and effective technique. This involves suturing a piece of the omentum over the perforation to seal it.

Graham patch repair for perforated peptic ulcer

High‑Yield Points - ⚡ Biggest Takeaways

  • Peptic ulcer disease, particularly duodenal ulcers, is the leading cause of GI perforation.
  • The classic presentation is sudden-onset, severe, diffuse abdominal pain followed by a rigid, board-like abdomen from peritonitis.
  • An upright chest X-ray is the best initial test to detect pneumoperitoneum (free air under the diaphragm).
  • Abdominal CT scan is the most sensitive imaging modality for diagnosis.
  • Management is an emergency: IV fluids, broad-spectrum antibiotics, and immediate exploratory laparotomy.

Practice Questions: Gastrointestinal perforation

Test your understanding with these related questions

A 66-year-old man is brought to the emergency department after a motor vehicle accident. The patient was a restrained passenger in a car that was struck on the passenger side while crossing an intersection. In the emergency department, he is alert and complaining of abdominal pain. He has a history of hyperlipidemia, gastroesophageal reflux disease, chronic kidney disease, and perforated appendicitis for which he received an interval appendectomy four years ago. His home medications include rosuvastatin and lansoprazole. His temperature is 99.2°F (37.3°C), blood pressure is 120/87 mmHg, pulse is 96/min, and respirations are 20/min. He has full breath sounds bilaterally. He is tender to palpation over the left 9th rib and the epigastrium. He is moving all four extremities. His FAST exam reveals fluid in Morrison's pouch. This patient is most likely to have which of the following additional signs or symptoms?

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Flashcards: Gastrointestinal perforation

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_____ of an anterior duodenal ulcer is characterized by free air under the diaphragm (pneumoperitoneum)

TAP TO REVEAL ANSWER

_____ of an anterior duodenal ulcer is characterized by free air under the diaphragm (pneumoperitoneum)

Perforation

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