Psychiatric comorbidities with sleep disorders

Psychiatric comorbidities with sleep disorders

Psychiatric comorbidities with sleep disorders

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Overview - The Bidirectional Bind

  • Vicious Cycle: Psychiatric illness disrupts sleep architecture, while poor sleep exacerbates or precipitates psychiatric symptoms.
  • High comorbidity: >50% of chronic insomnia patients have a co-occurring psychiatric disorder.
  • Key Links:
    • Depression ↔ Insomnia / Hypersomnia
    • Anxiety ↔ Sleep-onset insomnia
    • Bipolar (Mania) ↔ ↓ Sleep need
    • PTSD ↔ Nightmares, fragmented sleep

⭐ Treating insomnia in patients with depression can nearly double the likelihood of depression remission.

Depression & Insomnia - The Vicious Cycle

  • Bidirectional Link: Insomnia is a core symptom of Major Depressive Disorder (MDD) and a major risk factor for its development and recurrence.
    • Depression → Insomnia: Causes difficulty initiating/maintaining sleep & early morning awakenings (terminal insomnia).
    • Insomnia → Depression: Exacerbates depressive symptoms, increases relapse risk, and can blunt antidepressant response.
  • Shared Pathophysiology: Dysregulation of serotonin, norepinephrine, and HPA axis (↑ cortisol).

Adolescent sleep, psychiatric comorbidities

  • Sleep Architecture on PSG:
    • ↓ REM latency (pathognomonic)
    • ↑ REM density
    • ↓ Slow-wave sleep (N3)

Early morning awakening is a classic vegetative symptom highly suggestive of melancholic depression.

Anxiety Disorders & Sleep - Nighttime Worries

  • Anxiety drives cognitive & physiological hyperarousal, disrupting the sleep-wake cycle.
    • Characterized by racing thoughts, catastrophizing, and somatic tension, especially when trying to sleep.
    • Results in ↑ sleep latency and ↓ sleep maintenance (fragmented sleep).
  • Strongly associated with Generalized Anxiety Disorder (GAD) and Panic Disorder.
    • Nocturnal panic attacks: abrupt awakenings from NREM sleep in a state of intense fear.
  • Creates a vicious cycle where poor sleep worsens daytime anxiety.

⭐ The relationship is bidirectional. Insomnia is a key diagnostic criterion for GAD and often precedes or exacerbates it. Treating the primary anxiety disorder is crucial for resolving the associated insomnia.

Bipolar Disorder & Sleep - Manic Mayhem

  • Hallmark of mania: ↓ need for sleep (e.g., feeling rested on <3 hrs), distinct from insomnia where one wants to sleep but can't.
  • This is a core, high-energy symptom required for DSM-5 diagnosis.
  • Sleep deprivation itself can precipitate a switch into mania.
  • 📌 DIG FAST mnemonic highlights Sleep (decreased need) as central to mania.

⭐ Subjective decreased need for sleep is a highly specific prodromal symptom of a manic episode, making it a critical target for early intervention.

ADHD & Sleep - Can't Settle Down

  • Bidirectional link: ADHD's core symptoms (hyperarousal, inattention) disrupt sleep initiation and maintenance, while poor sleep worsens ADHD symptoms.
  • Common associated conditions:
    • Delayed Sleep-Wake Phase Disorder (DSWPD) - classic "night owl" chronotype.
    • Restless Legs Syndrome (RLS).
    • Behavioral insomnia of childhood.
  • Stimulant medications may cause insomnia, requiring careful dose timing.

⭐ Paradoxically, effective stimulant treatment can sometimes improve sleep by reducing ADHD-related arousal and improving self-regulation.

High‑Yield Points - ⚡ Biggest Takeaways

  • Depression is strongly linked to insomnia and hypersomnia; sleep disturbance is a core diagnostic criterion.
  • Anxiety disorders frequently present with difficulty initiating and maintaining sleep due to a state of hyperarousal.
  • PTSD is classically associated with distressing nightmares and disrupted sleep continuity.
  • A decreased need for sleep is a hallmark symptom of a manic episode in bipolar disorder.
  • ADHD is often comorbid with Restless Legs Syndrome (RLS) and Delayed Sleep Phase Disorder.

Practice Questions: Psychiatric comorbidities with sleep disorders

Test your understanding with these related questions

A 24-year-old woman presents with a 3-month history of worsening insomnia and anxiety. She says that she has an important college exam in the next few weeks for which she has to put in many hours of work each day. Despite the urgency of her circumstances, she states that she is unable to focus and concentrate, is anxious, irritable and has lost interest in almost all activities. She also says that she has trouble falling asleep and wakes up several times during the night. She claims that this state of affairs has severely hampered her productivity and is a major problem for her, and she feels tired and fatigued all day. She denies hearing voices, abnormal thoughts, or any other psychotic symptoms. The patient asks if there is some form of therapy that can help her sleep better so that she can function more effectively during the day. She claims that the other symptoms of not enjoying anything, irritability, and anxiety are things that she can learn to handle. Which of the following approaches is most likely to address the patients concerns most effectively?

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Flashcards: Psychiatric comorbidities with sleep disorders

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Agoraphobia is associated with _____ disorder

TAP TO REVEAL ANSWER

Agoraphobia is associated with _____ disorder

panic

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