Prodromal phase and early intervention

Prodromal phase and early intervention

Prodromal phase and early intervention

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Prodromal Phase - Whispers Before the Storm

  • Definition: Insidious, sub-threshold symptoms preceding the first psychotic episode. Can last months to years.
  • Presentation: Non-specific changes often noticed by family first.
    • Social: ↑ Withdrawal, isolation, suspiciousness.
    • Academic/Occupational: ↓ Performance, difficulty concentrating.
    • Mood: Anxiety, irritability, dysphoria.
    • Cognition: Vague, circumstantial speech; magical thinking.
    • Perception: Fleeting, attenuated positive symptoms (e.g., illusions, overvalued ideas).
  • Goal of Intervention: Delay or prevent conversion to full psychosis.
    • Management includes supportive psychotherapy, family therapy, and potentially low-dose antipsychotics.

High-Yield: The most significant predictor of conversion to psychosis is the presence and severity of attenuated positive symptoms (APS).

Natural History and Course of Schizophrenia Timeline

Risk & Assessment - Spotting the Signs

  • Genetic & Familial Risk:
    • Most significant factor: ~10% risk with a 1st-degree relative vs. 1% in general population.
    • Associated with specific gene variants (e.g., 22q11.2 deletion).
  • Environmental & Developmental Factors:
    • Perinatal: Hypoxia, maternal infection (influenza).
    • Social: Urban upbringing, migration, social adversity.
    • Substance Use: Heavy cannabis use in adolescence is a major precipitant.
  • Clinical High-Risk (CHR-P) Criteria:
    • Attenuated Positive Symptoms (APS): Subthreshold, reality-testing intact.
    • Brief Intermittent Psychotic Symptoms (BIPS): Frank psychosis, but brief & self-limited (< 1 week).
    • Genetic Risk + Functional Decline: Significant drop in GAF score + family history.

⭐ The transition rate from a clinical high-risk state to full-blown psychosis is approximately 20-35% within 2 years. Early detection is critical.

Early Intervention - Nipping It in the Bud

  • Goal: Delay or prevent transition to First-Episode Psychosis (FEP) in individuals at Clinical High Risk (CHR).
  • Core Strategies:
    • Cognitive Behavioral Therapy for Psychosis (CBTp): Addresses attenuated psychotic symptoms, cognitive biases, and distress.
    • Family Psychoeducation: Reduces high expressed emotion (HEE) and improves support systems.
    • Supportive Care: Includes case management, stress reduction, and academic/vocational support.
  • Pharmacotherapy (Use with caution):
    • Low-dose, time-limited atypical antipsychotics may be considered for severe or worsening symptoms.
    • ⚠️ Balance potential benefits against metabolic and extrapyramidal side effects.
    • Omega-3 fatty acids are an investigational option.

⭐ Reducing the Duration of Untreated Psychosis (DUP) is a critical prognostic factor improved by early intervention.

Differential Diagnosis - Rule-Out Roundup

  • Substance-Induced Psychosis: Rule out intoxication/withdrawal from cannabis, amphetamines, or hallucinogens.
  • Mood Disorders:
    • Major Depressive Disorder with psychotic features.
    • Bipolar I Disorder (psychosis during manic/depressive episodes).
  • Personality Disorders:
    • Consider Schizotypal, Schizoid, or Paranoid PD for long-standing interpersonal deficits.
  • Anxiety/Trauma: Severe OCD, Social Anxiety, or PTSD can mimic negative symptoms or paranoia.
  • Medical Conditions: Check for thyroid dysfunction, autoimmune disorders, CNS infections, or temporal lobe epilepsy.

⭐ Heavy cannabis use during adolescence is a significant risk factor, potentially doubling the risk for psychosis.

High‑Yield Points - ⚡ Biggest Takeaways

  • The prodromal phase precedes the first psychotic episode, featuring subtle, non-specific changes like social withdrawal and functional decline.
  • Key features include attenuated psychotic symptoms (e.g., suspiciousness, odd beliefs) that do not meet full criteria for psychosis.
  • Early intervention aims to delay or prevent conversion to psychosis through supportive psychotherapy and family education.
  • Antipsychotics are generally NOT indicated during the prodrome unless symptoms are severe or rapidly worsening.
  • A strong family history of schizophrenia is a major risk factor for conversion.

Practice Questions: Prodromal phase and early intervention

Test your understanding with these related questions

A 26-year-old woman is brought to the emergency department by her husband due to her disturbing behavior over the past 24 hours. Her husband says that he has noticed his wife talking to herself and staying in a corner of a room throughout the day without eating or drinking anything. She gave birth to their son 2 weeks ago but has not seen or even acknowledged her baby’s presence ever since he was born. He says that he didn’t think much of it because she seemed overwhelmed during her pregnancy and he considered that she was probably unable to cope with being a new mother; however, last night, he says, his wife told him that their child was the son of the devil and they ought to get rid of him as soon as possible. Which of the following describes this patient’s abnormal reaction to her child?

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Flashcards: Prodromal phase and early intervention

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Schizophrenia/psychosis in teens is associated with frequent _____ use

TAP TO REVEAL ANSWER

Schizophrenia/psychosis in teens is associated with frequent _____ use

cannabis

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