Positive symptoms

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Positive Symptoms & Dopamine - The Brain's Chatterbox

Positive symptoms are psychotic behaviors representing an excess or distortion of normal functions. They are highly responsive to antipsychotic medications.

  • Hallucinations: Sensory perception without external stimuli.
    • Most common: Auditory (e.g., hearing voices).
  • Delusions: Fixed, false beliefs resistant to contrary evidence (e.g., persecutory, grandiose).
  • Disorganized Speech: "Formal thought disorder." Manifests as tangentiality, loose associations, or "word salad."
  • Grossly Disorganized or Catatonic Behavior.

📌 Mnemonic: "DH" for Delusions & Hallucinations from Dopamine Hyperactivity.

Dopamine pathways in the human brain

⭐ Auditory hallucinations are the most common type in schizophrenia. In contrast, visual hallucinations are more suggestive of delirium, dementia, or substance-induced psychosis.

Delusions - Unshakable Beliefs

  • Fixed, false beliefs resistant to contrary evidence; not explained by cultural or religious background.
  • Types:
    • Persecutory: Most common; belief of being targeted for harm.
    • Grandiose: Inflated sense of self-worth, power, or identity.
    • Referential: Believing neutral events hold special personal meaning.
    • Control: Belief that an outside force controls one's body or thoughts (e.g., thought insertion/broadcasting).
    • Somatic: Preoccupation with health or organ function.
    • Erotomanic: False belief that another person is in love with them.

⭐ Delusions are deemed bizarre if clearly implausible and not understandable to same-culture peers (e.g., belief that an alien has replaced one's internal organs without leaving a scar). This is a key criterion for Schizophrenia.

Hallucinations - Sensory Deceptions

  • Sensory perceptions experienced without any external stimuli.
  • Auditory: The most frequent type in schizophrenia.
    • Often presents as voices that can be commanding, conversing, or providing a running commentary on the patient's actions.
    • Command hallucinations may present a danger to the patient or others.
  • Visual: Less common; their presence should prompt consideration of organic causes like delirium or substance use.
  • Tactile, Olfactory, Gustatory: Also less common in schizophrenia. May suggest other conditions (e.g., substance withdrawal, temporal lobe epilepsy).

⭐ Auditory hallucinations of voices arguing or discussing the patient in the third person are considered a Schneiderian first-rank symptom, highly indicative of schizophrenia.

Disorganized Speech & Behavior - Tangled Talk & Actions

  • Disorganized Speech (Formal Thought Disorder): Thinking lacks logical connections, reflected in speech.
    • Loose Associations (Derailment): Unrelated ideas shift abruptly.
    • Tangentiality: Wanders off-point, never returning.
    • Circumstantiality: Excessive, irrelevant detail but eventually answers.
    • Incoherence ("Word Salad"): Jumbled, meaningless words.
    • Neologisms: Made-up words.
    • Clang Associations: Words chosen based on sound/rhyme.
  • Disorganized/Bizarre Behavior: Loss of goal-directed activity.
    • Catatonic Excitement: Purposeless motor activity.
    • Inappropriate Affect: Mismatched emotional expression.
    • Decline in daily functioning (e.g., hygiene, meals).
    • Agitation, stereotypy (repetitive movements).

High-Yield: Formal thought disorder, especially loose associations, is a core feature of schizophrenia and a strong predictor of poor long-term functional outcome.

High-Yield Points - ⚡ Biggest Takeaways

  • Positive symptoms are psychotic behaviors not seen in healthy people, including hallucinations, delusions, and disorganized speech/behavior.
  • Auditory hallucinations are the most common type reported in schizophrenia.
  • The core pathophysiology is dopamine hyperactivity in the brain's mesolimbic pathway.
  • They are the main target of antipsychotic medications (e.g., D2 antagonists).
  • Positive symptoms are typically more responsive to treatment than negative symptoms.
  • Distinguishing from negative symptoms (avolition, alogia) is key for diagnosis.

Practice Questions: Positive symptoms

Test your understanding with these related questions

A 40-year-old male accountant is brought to the physician by his wife. She complains of her husband talking strangely for the past 6 months. She has taken him to multiple physicians during this time, but her husband did not comply with their treatment. She says he keeps things to himself, stays alone, and rarely spends time with her or the kids. When asked how he was doing, he responds in a clear manner with "I am fine, pine, dine doc." When further questioned about what brought him in today, he continues “nope, pope, dope doc.” Physical examination reveals no sensorimotor loss or visual field defects. Which of the following best describes the patient's condition?

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Flashcards: Positive symptoms

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What group of drugs is the first line treatment for schizophrenia? _____

TAP TO REVEAL ANSWER

What group of drugs is the first line treatment for schizophrenia? _____

Atypical antipsychotics (e.g. risperidone)

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