Borderline personality disorder

Borderline personality disorder

Borderline personality disorder

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BPD Overview - Edge of Stability

  • A pervasive pattern of instability in interpersonal relationships, self-image, and affect, coupled with marked impulsivity beginning by early adulthood.
  • Core features include frantic efforts to avoid real or imagined abandonment, a pattern of unstable and intense relationships, and chronic feelings of emptiness.
  • Impulsivity in at least 2 self-damaging areas (spending, sex, substance abuse) is characteristic.

⭐ The hallmark defense mechanism is splitting-alternating between extremes of idealization and devaluation.

📌 Mnemonic: AM SUICIDE

Clinical Features - 'AM SUICIDE' Criteria

📌 AM SUICIDE

  • Abandonment: Frantic efforts to avoid real or imagined abandonment.
  • Mood Instability: Intense episodic dysphoria, irritability, or anxiety.
  • Suicidal Behavior: Recurrent suicidal gestures, threats, or self-mutilation.
  • Unstable Relationships: Pattern of intense relationships, alternating between idealization and devaluation (splitting).
  • Impulsivity: In ≥2 potentially self-damaging areas (spending, sex, substance abuse).
  • Control of Anger: Inappropriate, intense anger or difficulty controlling it.
  • Identity Disturbance: Markedly unstable self-image or sense of self.
  • Dissociative/Paranoid Symptoms: Transient, stress-related paranoid ideation or dissociation.
  • Emptiness: Chronic feelings of emptiness.

Splitting is a key defense mechanism, viewing people and situations in "all-or-nothing," black-or-white terms, which fuels the cycle of idealization and devaluation in relationships.

Pathophysiology - Brain, Genes & Trauma

  • Neurobiology:
    • Brain Circuits: ↑ Amygdala activation (emotional intensity) & ↓ Prefrontal Cortex (PFC) modulation (impulsivity).
    • Neurotransmitters: Dysregulation of the serotonin (5-HT) system is strongly implicated.
  • Genetic Predisposition: High heritability; genetic factors account for a significant portion of the risk.
  • Environmental Factors: Invalidating childhood environment, including abuse (physical, sexual) and neglect, is a major risk factor.

⭐ A history of childhood trauma, particularly sexual abuse, is found in ~70% of individuals with BPD.

Differential Diagnosis - BPD vs. The World

  • Bipolar II Disorder: BPD mood shifts are rapid, reactive (hours), lacking sustained hypomanic episodes (days-weeks).
  • Histrionic PD: BPD involves more self-destruction, chronic emptiness, and identity disturbance vs. HPD's theatricality.
  • Dependent PD: Abandonment fear in BPD → rage, impulsivity. In DPD → submissiveness, clinging.
  • Schizotypal PD: BPD's paranoia is transient & stress-related; STPD's is pervasive & eccentric.

⭐ BPD's affective instability is rapid (hours) and reactive to interpersonal events, unlike the sustained mood episodes (days-weeks) of Bipolar Disorder.

Management - DBT to the Rescue

  • Psychotherapy is the cornerstone; Dialectical Behavior Therapy (DBT) is first-line.
  • DBT integrates cognitive-behavioral techniques with mindfulness, focusing on:
    • Mindfulness
    • Distress Tolerance
    • Emotion Regulation
    • Interpersonal Effectiveness
  • Pharmacotherapy treats co-morbid conditions (e.g., depression, anxiety) but not core BPD symptoms.
    • SSRIs, mood stabilizers, or antipsychotics may be used adjunctively.

High-Yield: No medications are FDA-approved specifically for the treatment of borderline personality disorder itself; pharmacotherapy targets co-occurring symptoms or disorders.

  • Instability in mood, relationships, and self-image is the core feature.
  • Intense fear of abandonment drives many of the behaviors.
  • Splitting is a key defense mechanism: viewing people and situations as either all-good or all-bad.
  • Associated with impulsivity (e.g., spending, sex, substance use) and recurrent suicidal gestures or self-mutilation.
  • Patients often report chronic feelings of emptiness.
  • Dialectical Behavioral Therapy (DBT) is the most effective, first-line treatment.

Practice Questions: Borderline personality disorder

Test your understanding with these related questions

A 23-year-old woman is brought to the emergency room by her mother after she is found to have cut both of her wrists with razor blades. The patient admits to a history of self-mutilation and attributed this incident to a recent breakup with a man she had been seeing for the previous 2 weeks. On morning rounds, the patient reports that the nurses are incompetent but the doctors are some of the best in the world. The patient's vitals are stable and her wrist lacerations are very superficial requiring only simple dressings without sutures. The patient is discharged a few days later and she feels well. Which of the following is the most appropriate initial treatment for this patient?

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Flashcards: Borderline personality disorder

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Borderline personality disorder is more common in _____ (gender)

TAP TO REVEAL ANSWER

Borderline personality disorder is more common in _____ (gender)

females

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