Course and prognosis

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Course of Illness - The Unwavering Belief

  • Onset: Typically insidious, occurring in middle to late adult life (40-55 years).
  • Course: Chronic and lifelong with stable, non-bizarre delusions.
    • Functional impairment is usually circumscribed to the delusion's theme.
    • Social, occupational, and daily functioning remain largely intact otherwise.
  • Prognosis varies:
    • Favorable factors: Female, acute onset, shorter illness duration, good premorbid adjustment.
    • Unfavorable factors: Male, insidious onset, long duration, poor premorbid functioning.
  • Remission: Full remission is uncommon; partial remission or symptomatic fluctuation is more typical.

High-Yield: A significant minority of individuals with delusional disorder, estimated to be up to one-third, may eventually have their diagnosis revised to schizophrenia, highlighting the importance of long-term follow-up.

Prognostic Factors - Reading the Signs

  • Good Prognostic Factors:

    • High levels of occupational and social functioning.
    • Female sex.
    • Onset before age 30.
    • Sudden onset of symptoms.
    • Short duration of illness.
  • Poor Prognostic Factors:

    • Insidious onset and chronic course.
    • Male sex.
    • Presence of somatic, paranoid, or erotomanic delusions.
    • Poor premorbid adjustment.
    • Comorbid personality disorders (e.g., paranoid, schizoid).

Overall Prognosis: Approximately 50% of patients experience full recovery, 20% show a decrease in symptoms, and 30% have persistent, non-remitting symptoms.

Remission & Complications - Living with Delusion

  • Remission Rates:

    • Spontaneous remission is rare; course is often chronic.
    • With treatment, ~50% of patients experience a significant reduction in symptoms.
    • Full remission occurs in only ~20% of cases.
    • Functioning outside the specific delusion often remains preserved.
  • Common Complications:

    • Social & Occupational: ↑ isolation, marital discord, job loss (especially if delusion is work-related).
    • Legal: Risk of litigation (querulous subtype) or arrest, particularly with persecutory or jealous types.
    • Mood Disorders: High comorbidity with major depression, often developing after the delusion.

⭐ A key prognostic indicator is the patient's premorbid level of functioning. High-functioning individuals with good social support tend to have better outcomes, even if the delusion itself persists.

High‑Yield Points - ⚡ Biggest Takeaways

  • Delusional disorder is a stable, chronic illness; delusions are often lifelong.
  • Prognosis is better than schizophrenia but worse than mood disorders.
  • Global functioning is surprisingly well-preserved outside the delusion's direct impact.
  • Good prognostic factors: female sex, onset before age 30, sudden onset, and short illness duration.
  • Poor prognostic factors: insidious onset, male sex, and comorbid somatic complaints.
  • Transformation into schizophrenia is rare.

Practice Questions: Course and prognosis

Test your understanding with these related questions

A 35-year-old woman is brought to the inpatient psychiatric unit by the police after she was found violating the conditions of her restraining order by parking on the side street of her "lover’s" home every night for the past week. Her "lover", a famous hometown celebrity, has adamantly denied any relationship with the patient over the past 6 months. The patient insists that ever since he signed a copy of his album at a local signing, she knew they were in love. Despite him having his own wife and children, the patient insists that he is in love with her and goes to his house to meet in secret. Physical examination of the patient is unremarkable. Urine toxicology is negative. Which of the following statements best describes this patient’s condition?

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Flashcards: Course and prognosis

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Do the complaints associated with malingering cease after the desired gain? _____

TAP TO REVEAL ANSWER

Do the complaints associated with malingering cease after the desired gain? _____

Yes

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