Anxiety disorder differential diagnosis

Anxiety disorder differential diagnosis

Anxiety disorder differential diagnosis

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DDx Overview - The Anxiety Spectrum

  • Generalized Anxiety Disorder (GAD): Chronic, excessive worry about various topics for ≥ 6 months.
  • Panic Disorder: Recurrent, unexpected panic attacks with persistent fear of having more.
  • Agoraphobia: Intense fear of ≥ 2 situations where escape may be difficult.
  • Social Anxiety Disorder: Marked fear of social situations and potential scrutiny.
  • Specific Phobia: Overwhelming fear of a single object or situation, leading to avoidance.

⭐ Panic disorder and agoraphobia are distinct diagnoses; many patients with agoraphobia do not have panic disorder.

Panic Disorder vs. GAD - Sudden vs. Steady

FeaturePanic DisorderGeneralized Anxiety Disorder (GAD)
OnsetSudden, discrete attacksPervasive, chronic worry
DurationPeaks in minutes"More days than not" for ≥ 6 months
FocusFear of future attacksMultiple real-life domains (work, money)
Key SxUnexpected panic attacksRestlessness, fatigue, poor concentration
Timeline1 month of worry/avoidance6 months of excessive anxiety

Exam Pearl: The worry in Panic Disorder is focused on the panic attack itself (fear of the fear), while GAD worry is "free-floating" and attaches to numerous everyday stressors.

Social Anxiety vs. Agoraphobia - Fear of Crowds or Critics?

  • Social Anxiety Disorder (SAD): Fear of scrutiny & negative judgment.
    • Triggers: Performance or social situations (e.g., public speaking, parties).
    • Core thought: "They will think I'm stupid/awkward."
  • Agoraphobia: Fear of situations where escape may be difficult if panic occurs.
    • Triggers: Crowds, public transport, open spaces, being outside home alone.
    • Core thought: "I'll be trapped and unable to get help."

Diagnostic Pearl: A person with agoraphobia might feel safe in a crowd with a trusted companion, whereas someone with SAD fears the scrutiny regardless of company.

OCD & PTSD - Intrusions & Trauma

  • Obsessive-Compulsive Disorder (OCD)

    • Intrusive thoughts (obsessions) are ego-dystonic; internally generated fears unrelated to a past trauma.
    • Compulsions are repetitive acts aimed at neutralizing anxiety or preventing a dreaded event.
  • Post-Traumatic Stress Disorder (PTSD)

    • Intrusions are re-experiencing a specific, past traumatic event (e.g., flashbacks, nightmares).
    • Characterized by persistent avoidance of stimuli associated with the trauma.

Exam Tip: The core distinction lies in the content of the intrusion. OCD fears are often irrational and not based on a real past event, whereas PTSD intrusions are a direct reliving of a real, historical trauma.

Medical Mimics - It's Not All in the Head

  • Endocrine: Hyperthyroidism, pheochromocytoma, hypoglycemia, Cushing's syndrome.
  • Cardiopulmonary: Myocardial infarction, pulmonary embolism, arrhythmias (e.g., SVT), asthma/COPD.
  • Neurologic: Seizure disorders (especially temporal lobe), vestibular dysfunction, neoplasms.
  • Substance-Related: Caffeine intoxication, stimulant use (cocaine, amphetamines), alcohol/sedative withdrawal, medication side effects (steroids, bronchodilators).

Endocrine Glands and Organs Related to Anxiety Symptoms

⭐ Always consider pheochromocytoma in patients with episodic anxiety, headaches, diaphoresis, and treatment-resistant hypertension.

High‑Yield Points - ⚡ Biggest Takeaways

  • Panic disorder involves recurrent, unexpected attacks; agoraphobia is fear of situations where escape is difficult.
  • GAD is excessive, multi-topic worry for >6 months, distinguishing it from normal anxiety.
  • Social anxiety centers on fear of scrutiny, while agoraphobia focuses on inescapable situations.
  • OCD is ego-dystonic (distressing), whereas OCPD is ego-syntonic (part of self-identity).
  • Symptom duration distinguishes PTSD (>1 month) from acute stress disorder (<1 month).
  • Rule out medical causes like hyperthyroidism, pheochromocytoma, and caffeine/stimulant use.

Practice Questions: Anxiety disorder differential diagnosis

Test your understanding with these related questions

A 30-year-old woman comes to the physician because of difficulty sleeping. She is afraid of falling asleep and gets up earlier than desired. Four months ago, she was the driver in a car accident that resulted in the death of her unborn child. She has vivid nightmares of the event and reports that she frequently re-experiences the accident. She blames herself for the death of her child, has stopped working as an accountant, avoids driving in cars, and has withdrawn from her parents and close friends. Which of the following is the most likely diagnosis?

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Flashcards: Anxiety disorder differential diagnosis

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Agoraphobia is associated with _____ disorder

TAP TO REVEAL ANSWER

Agoraphobia is associated with _____ disorder

panic

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