Agoraphobia

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Agoraphobia - Fear of Open Spaces

  • Marked fear or anxiety about ≥2 of the following situations:
    • Using public transportation
    • Being in open spaces (e.g., parking lots, bridges)
    • Being in enclosed spaces (e.g., shops, theaters)
    • Standing in line or being in a crowd
    • Being outside of the home alone
  • Fears that escape might be difficult if panic-like symptoms develop.
  • Symptoms must last for ≥6 months.
  • Treatment: Cognitive Behavioral Therapy (CBT) and SSRIs are first-line.

⭐ While often co-occurring, a diagnosis of agoraphobia can be made independent of panic disorder.

Diagnosis - The DSM-5 Blueprint

Deenz Agoraphobia Scale: Symptoms and Impact

  • Core Criterion: Marked fear or anxiety about ≥2 of the following situations, fearing that escape might be difficult or help unavailable if panic-like symptoms occur.
    • 📌 Mnemonic: PLACES
    • Public transportation
    • Large, open spaces (e.g., parking lots, bridges)
    • Alone outside the home
    • Crowds or standing in line
    • Enclosed spaces (e.g., theaters, shops)
  • Duration: Symptoms persist for ≥6 months.
  • Impact: Causes clinically significant distress or functional impairment.
  • Exclusion: Not better explained by another mental disorder.

High-Yield: Agoraphobia can be diagnosed irrespective of the presence of panic disorder. About 30-50% of individuals with agoraphobia have no history of panic attacks.

Differential Diagnosis - Ruling Out Mimics

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Treatment - The Escape Route

  • First-Line Gold Standard: Combination of Cognitive Behavioral Therapy (CBT) and SSRIs.
    • 📌 Surely Safe Route Is Sertraline/Fluoxetine.
    • Start low, titrate slow to minimize initial anxiogenic effects.
  • Cognitive Behavioral Therapy (CBT): The cornerstone of treatment.
    • Focuses on exposure therapy; gradual, repeated confrontation of feared situations (in vivo exposure is most effective).
    • Includes psychoeducation, breathing/relaxation techniques, and cognitive restructuring.
  • Pharmacotherapy Algorithm:

High-Yield: The single most effective component of CBT for agoraphobia is in vivo exposure. Patients must physically enter and remain in feared situations until anxiety subsides.

Anxiety and habituation cycle in exposure therapy

  • Second-Line/Adjuncts:
    • SNRIs (e.g., Venlafaxine) are effective alternatives.
    • ⚠️ Benzodiazepines (e.g., Alprazolam, Clonazepam) for severe, acute symptoms or short-term bridging. High risk of dependence; avoid long-term monotherapy.

High‑Yield Points - ⚡ Biggest Takeaways

  • Agoraphobia is an intense fear of ≥2 situations (e.g., public transport, open spaces, crowds) where escape might be difficult.
  • The core fear revolves around developing panic-like symptoms and being unable to receive help.
  • Feared situations are actively avoided, require a companion, or are endured with intense anxiety.
  • Symptoms must be persistent, lasting for ≥6 months.
  • High comorbidity with panic disorder; specify if present.
  • First-line treatment is SSRIs and CBT (exposure therapy).

Practice Questions: Agoraphobia

Test your understanding with these related questions

A 24-year-old male graduate student comes to the physician for a two-month history of repeated thoughts and anxiety that he is going to be harmed by someone on the street. The anxiety worsened after witnessing a pedestrian getting hit by a car two weeks ago. He says, “That was a warning sign.” On his way to school, he now often leaves an hour earlier to take a detour and hide from people that he thinks might hurt him. He is burdened by his coursework and fears that his professors are meaning to fail him. He says his friends are concerned about him but that they do not understand because they were not present at the accident. The patient has no known history of psychiatric illness. On mental status exam, he is alert and oriented, and shows full range of affect. Thought processes and speech are organized. His memory and attention are within normal limits. He denies auditory, visual, or tactile hallucinations. Urine toxicology screening is negative. Which of the following is the most likely diagnosis in this patient?

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Flashcards: Agoraphobia

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Agoraphobia is associated with _____ disorder

TAP TO REVEAL ANSWER

Agoraphobia is associated with _____ disorder

panic

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