Physiology of Lactation - The Milky Way

- Lactogenesis (Production): Driven by Prolactin (Anterior Pituitary). Suckling ↑ levels.
- Galactokinesis (Ejection): Mediated by Oxytocin (Posterior Pituitary) → myoepithelial cell contraction (let-down reflex).
- Galactopoiesis (Maintenance): Regular suckling is crucial to maintain production by stimulating prolactin and oxytocin release.
- Autocrine Control: Feedback Inhibitor of Lactation (FIL) in whey protein; milk stasis → ↑FIL → ↓ production.
⭐ Progesterone withdrawal after placental delivery removes its inhibitory effect on prolactin, initiating copious milk secretion (Lactogenesis Stage II) within 48-72 hours.
Breast Milk Composition - Nature's Liquid Gold
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Types of Milk
- Colostrum (First 3-4 days): Low volume, high density. Rich in secretory IgA, lactoferrin, Vitamin A, leukocytes.
- Transitional Milk (Day 5-14): Gradual change; ↑ fat & lactose.
- Mature Milk (After 14 days): Separated into:
- Foremilk: Watery, high lactose; quenches thirst.
- Hindmilk: Opaque, high fat; provides energy & satiety.
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Key Components vs. Cow's Milk
- Energy: 65-70 kcal/dL.
- Proteins (0.9 g/dL): Whey dominant. Whey:Casein ratio is 60:40.
- Fats (3.5 g/dL): Rich in LCPUFAs (DHA, ARA) for neurodevelopment.
- Carbohydrates (7 g/dL): Primarily Lactose. Oligosaccharides act as prebiotics.
⭐ Human milk's Whey:Casein ratio is 60:40, promoting easy digestion. Cow's milk is reversed at 20:80, forming a harder curd.
Breastfeeding Technique - The Perfect Latch

Signs of a Good Latch (Attachment):
- Mouth wide open
- Lower lip flanged outwards
- Chin touching the breast
- More areola visible above the baby's mouth than below
Effective Suckling Indicators:
- Slow, deep sucks with occasional pauses
- Audible swallowing sounds
- Cheeks are full and rounded, not drawn in
- Mother feels a drawing/tugging sensation, not pain
- Baby releases the breast spontaneously after a feed
⭐ Exam Favourite: Pain is a sign of a poor latch. The baby should take a large mouthful of breast tissue, not just the nipple, to prevent nipple soreness and ensure adequate milk transfer.
Common Breastfeeding Problems - Nipple 911
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Sore/Cracked Nipples: Most common cause is poor latching.
- Management: Correct positioning & latch. Apply expressed breast milk (EBM) or purified lanolin. Air-dry nipples.
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Nipple Vasospasm (Raynaud's): Intermittent ischemia from cold/latch issues.
- Symptoms: Triphasic color change (white → blue → red/purple) with severe, throbbing pain.
- Management: Warm compresses. Avoid cold exposure. Nifedipine may be prescribed.
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Inverted/Flat Nipples: Assessed with the 'pinch test'; nipple retracts or doesn't protrude.
- Management: Hoffman's maneuver, modified syringe suction before feeds, nipple shields.
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Candida Infection: Burning, stinging pain; nipples may be pink, shiny, or flaky.
- Management: Topical miconazole/clotrimazole for mother & oral nystatin for baby (if thrush present).
⭐ Most common cause of nipple pain in the first week of breastfeeding is improper infant positioning and latch.

- Absolute contraindications to breastfeeding include galactosemia in the infant, and active untreated TB or HIV (in developed nations) in the mother.
- Prolactin from the anterior pituitary governs milk synthesis; oxytocin from the posterior pituitary controls the milk ejection reflex.
- The LATCH score is a standardized tool for assessing breastfeeding technique immediately postpartum.
- Breast engorgement involves bilateral, diffuse swelling, whereas mastitis is typically unilateral, focal, and associated with fever.
- Breastfeeding significantly reduces infant risk of otitis media, gastroenteritis, and necrotizing enterocolitis.
- For the mother, lactation lowers the risk of breast and ovarian cancer.
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