Blood and tissue parasites

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Plasmodium Species - Malaria Mayhem

  • Transmission: Anopheles mosquito injects sporozoites → infect liver (exo-erythrocytic cycle) → release merozoites → infect RBCs (erythrocytic cycle).
    • P. vivax & P. ovale have dormant liver forms (hypnozoites).
  • Clinical Features: Cyclical fever, chills, sweats, headache, splenomegaly, hemolytic anemia.
    • Fever Patterns:
      • P. falciparum: Irregular, most severe (cerebral malaria).
      • P. vivax/ovale: Tertian (fever every 48 hrs).
      • P. malariae: Quartan (fever every 72 hrs).
  • Diagnosis: Giemsa-stained blood smear.
    • P. falciparum: Multiple ring forms per RBC; banana-shaped gametocytes.

Plasmodium on Giemsa stain: Thick vs. Thin blood smears

⭐ Duffy antigen negativity confers resistance to P. vivax infection, common in individuals of West African descent.

Other Blood Protozoa - Bad Blood Bugs

  • Babesia microti
    • Vector: Ixodes tick (risk of co-infection with Lyme disease, Anaplasma).
    • Clinical: Presents with fever and hemolytic anemia. Disease is more severe in asplenic patients.
    • Diagnosis: Blood smear reveals intra-erythrocytic ring forms and pathognomonic Maltese cross tetrads.
    • Treatment: Atovaquone + azithromycin.
    • Babesia microti Maltese cross in blood smear
  • Trypanosoma cruzi (Chagas Disease)
    • Vector: Reduviid bug (the "kissing bug").
    • Transmission: Contamination of a bite wound with insect feces.
    • Chronic Phase: Leads to dilated cardiomyopathy, megacolon, and megaesophagus.
    • Diagnosis: Visualization of trypomastigotes on a peripheral blood smear.

⭐ In Chagas disease, cardiac involvement is the most serious chronic manifestation, often leading to heart failure and death. The parasite directly damages myocardial tissue.

Key Tissue Protozoa - Flesh-Eating Freaks

  • Naegleria fowleri

    • Source: Warm freshwater, enters via cribriform plate (e.g., swimming, nasal irrigation).
    • Disease: Primary Amebic Meningoencephalitis (PAM) → rapidly fatal.
    • Dx: Motile trophozoites in CSF.
    • Rx: Amphotericin B, but often ineffective due to late diagnosis.
  • Acanthamoeba castellanii

    • Source: Contaminated water (tap water, soil, contact lens solution).
    • Diseases:
      • Keratitis: Eye pain, redness, corneal ulcers (associated with contact lenses).
      • Granulomatous Amebic Encephalitis (GAE): In immunocompromised patients.
    • Dx: Cysts in tissue biopsy.
  • Balamuthia mandrillaris

    • Source: Soil, dust.
    • Disease: GAE, similar to Acanthamoeba.

High-Yield: Naegleria fowleri causes a fulminant, hemorrhagic meningoencephalitis, with death occurring within 1-2 weeks of symptom onset. It is almost universally fatal.

Naegleria fowleri trophozoites in CSF wet mount

Tissue Helminths - Worming Their Way In

  • Taenia solium (Pork Tapeworm) → Cysticercosis
    • Ingestion of eggs from human feces leads to larvae encysting in tissues.
    • Neurocysticercosis: Brain cysts cause seizures, headaches, and hydrocephalus.
    • Dx: Brain CT/MRI shows "Swiss cheese" appearance.

Neurocysticercosis: Brain CT with multiple calcified cysts

  • Echinococcus granulosus (Dog Tapeworm) → Hydatid Disease

    • Ingestion of eggs from dog feces; cysts form in liver and lungs.
    • Dx: Imaging shows large cysts with "eggshell calcification."
    • ⚠️ Cyst rupture can trigger anaphylactic shock.
  • Trichinella spiralis (Pork Roundworm) → Trichinosis

    • Ingestion of larvae in undercooked pork or wild game.
    • Classic triad: periorbital edema, myalgia, and marked eosinophilia.

⭐ Neurocysticercosis is a leading cause of adult-onset seizures worldwide.

  • Malaria presents with cyclical fevers; P. falciparum is the most severe species, causing cerebral malaria and irregular high fevers.
  • Toxoplasma gondii causes ring-enhancing brain lesions in AIDS patients and the classic triad of chorioretinitis, hydrocephalus, and intracranial calcifications in congenital infection.
  • Trypanosoma cruzi (Chagas disease) leads to cardiomyopathy, megacolon, and megaesophagus.
  • Babesia shows a "Maltese cross" on blood smear and is particularly severe in asplenic patients.
  • Leishmania, transmitted by sandflies, causes cutaneous ulcers or visceral disease (kala-azar).
  • Naegleria fowleri causes a rapidly fatal meningoencephalitis after swimming in warm freshwater.

Practice Questions: Blood and tissue parasites

Test your understanding with these related questions

A 42-year-old woman comes to the physician because of episodic abdominal pain and fullness for 1 month. She works as an assistant at an animal shelter and helps to feed and bathe the animals. Physical examination shows hepatomegaly. Abdominal ultrasound shows a 4-cm calcified cyst with several daughter cysts in the liver. She undergoes CT-guided percutaneous aspiration under general anesthesia. Several minutes into the procedure, one liver cyst spills, and the patient's oxygen saturation decreases from 95% to 64%. Her pulse is 136/min, and blood pressure is 86/58 mm Hg. Which of the following is the most likely causal organism of this patient's condition?

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Flashcards: Blood and tissue parasites

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How is Babesiosis (Babesia spp.) transmitted?_____

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How is Babesiosis (Babesia spp.) transmitted?_____

Ixodes tick

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