Shock classification and management

Shock classification and management

Shock classification and management

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Shock Pathophysiology - Cellular Crisis Mode

  • Inadequate tissue perfusion (↓ DO₂) forces cells into anaerobic glycolysis.
    • ATP production plummets: $C_6H_{12}O_6 \to 2 \text{ ATP} + \text{Lactate}$.
    • Lactic acidosis (↑ serum lactate > 2 mmol/L) develops.
  • Failure of Na⁺/K⁺-ATPase pump → cellular edema, lysosomal rupture, and cell death (necrosis/apoptosis).
  • Mitochondrial dysfunction becomes irreversible, sealing cell fate.

Mitochondrial electron transport chain and ATP synthesis

⭐ The transition to irreversible shock is marked by widespread mitochondrial failure, rendering cells unable to use oxygen even if perfusion is restored.

Shock Types - The Four Horsemen

  • Hypovolemic: Loss of intravascular volume (e.g., hemorrhage, dehydration).
  • Cardiogenic: Primary myocardial pump failure (e.g., MI, heart failure).
  • Distributive: Severe peripheral vasodilation (e.g., sepsis, anaphylaxis, neurogenic).
  • Obstructive: Extracardiac obstruction to blood flow (e.g., PE, tamponade, tension pneumothorax).

Hemodynamic Profiles of Different Types of Shock

Shock TypeCVP (Preload)PCWP (Preload)CO (Pump)SVR (Afterload)
Hypovolemic
Cardiogenic
Distributive↑ (early) / ↓ (late)
ObstructiveN/↓

Patient Presentation - Reading The Signs

  • General Signs of Hypoperfusion:

    • Hypotension (MAP < 65 mmHg), tachycardia, tachypnea.
    • Altered mental status.
    • Cool, clammy skin; oliguria (< 0.5 mL/kg/hr).
  • Key Differentiators:

    • Cardiogenic: JVD, pulmonary edema (crackles).
    • Hypovolemic: Flat neck veins, dry mucosa.
    • Distributive (Septic): Fever, warm/flushed skin (early).
    • Obstructive (Tamponade): Beck's Triad (JVD, hypotension, muffled heart sounds).

image

⭐ Neurogenic shock is unique: presents with hypotension and bradycardia following spinal injury.

Initial Response - Stabilize & Scramble

  • ABCs: Airway, Breathing, Circulation. Prioritize immediate life threats.
  • Access: Two large-bore (≥16G) peripheral IVs. Administer O₂.
  • Action: Start IV fluid resuscitation, typically 30 mL/kg crystalloid bolus for hypotension.

⭐ Serum lactate > 2 mmol/L is a key indicator of tissue hypoperfusion and is associated with increased mortality in shock.

Targeted Treatment - Pick Your Poison

  • Cardiogenic: ↓ Contractility → Inotropes (Dobutamine), Diuretics. If hypotensive, use Norepinephrine.
  • Hypovolemic: ↓ Preload → Aggressive fluid resuscitation (crystalloids, blood). Vasopressors if refractory.
  • Distributive: Massive vasodilation.
    • Septic: Norepinephrine is the first-line vasopressor. Add broad-spectrum antibiotics.
    • Anaphylactic: Epinephrine (IM first!), antihistamines, corticosteroids.
    • Neurogenic: Norepinephrine or Phenylephrine to restore vascular tone.
  • Obstructive: Relieve the physical obstruction.
    • Tamponade → Pericardiocentesis.
    • Tension Pneumothorax → Needle decompression.
    • Pulmonary Embolism → Thrombolysis/Thrombectomy.

Vasopressor and Inotrope Activity Chart

⭐ In septic shock, if Mean Arterial Pressure (MAP) remains < 65 mmHg despite adequate fluid resuscitation, initiate Norepinephrine within the first hour to improve perfusion.

High‑Yield Points - ⚡ Biggest Takeaways

  • Distributive shock (septic, anaphylactic) is marked by ↓ Systemic Vascular Resistance (SVR). Septic shock requires IV fluids, broad-spectrum antibiotics, and vasopressors (norepinephrine).
  • Cardiogenic shock presents with ↓ Cardiac Output (CO) and ↑ Pulmonary Capillary Wedge Pressure (PCWP). Use inotropes (dobutamine), not aggressive fluids.
  • Hypovolemic shock shows ↓ preload (CVP, PCWP) and ↓ CO. Treat with aggressive volume resuscitation.
  • Obstructive shock (e.g., PE, tamponade) has ↓ CO from obstruction; treat the underlying cause urgently.

Practice Questions: Shock classification and management

Test your understanding with these related questions

A 16-year-old girl is brought to the emergency room with hyperextension of the cervical spine caused by a trampoline injury. After ruling out the possibility of hemorrhagic shock, she is diagnosed with quadriplegia with neurogenic shock. The physical examination is most likely to reveal which of the following constellation of findings?

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Flashcards: Shock classification and management

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Which major medical insurance plan limits patients to a network of doctors, specialists, and hospitals without requirement of referrals?_____

TAP TO REVEAL ANSWER

Which major medical insurance plan limits patients to a network of doctors, specialists, and hospitals without requirement of referrals?_____

Exclusive provider organization (EPO)

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