Altered mental status approach

Altered mental status approach

Altered mental status approach

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AMS Triage - First Five Moves

Glasgow Coma Scale (GCS) components and scoring

  • ABCs & Vitals: Secure airway (intubate if GCS ≤ 8), ensure adequate breathing/circulation, get a full set of vitals.
  • Check Glucose: Immediate fingerstick. If <70 mg/dL, give 50mL of D50W IV.
  • IV, O₂, Monitor: Establish IV access, apply supplemental oxygen, and place on a cardiac monitor.
  • "Coma Cocktail": Consider based on clinical suspicion:
    • Thiamine (100mg IV): Give before glucose in suspected alcohol use disorder or malnutrition.
    • Naloxone (0.4-2mg IV/IM): For suspected opioid overdose (respiratory depression, pinpoint pupils).
  • Initial Labs/Data: Draw blood for basic labs (CBC, BMP, LFTs, coags, tox screen), get an EKG, and a focused history (AMPLE).

Wernicke's Prevention: Always administer thiamine before glucose in patients with suspected chronic alcohol use or malnourishment to prevent precipitating Wernicke-Korsakoff Syndrome.

The AMS Jigsaw - Finding the Cause

Differential Diagnosis for Altered Mental Status

📌 AEIOU-TIPS Mnemonic:

  • Alcohol, Acidosis (DKA), Ammonia
  • Electrolytes (esp. Na⁺), Endocrine (thyroid, adrenal), Encephalopathy
  • Infection: Sepsis (UTI, PNA), CNS (meningitis/encephalitis)
  • Opioids, Oxygen (hypoxia/hypercarbia)
  • Uremia
  • Trauma (TBI, subdural), Temperature, Toxins (TCAs, salicylates)
  • Insulin (hypo/hyperglycemia)
  • Psychiatric, Poisons
  • Stroke, Seizure (post-ictal, non-convulsive), Subarachnoid Hemorrhage

⭐ In a patient with suspected alcohol use disorder and AMS, always administer thiamine before glucose to prevent precipitating Wernicke's encephalopathy.

Detective Work - Lab & Scan Plan

  • Tier 1: Immediate & Bedside
    • Fingerstick glucose: The fastest check.
    • Vitals & EKG: Rule out hemodynamic or arrhythmic causes.
  • Tier 2: Core Labs
    • Bloodwork: CBC, BMP, LFTs, ammonia, coagulation panel.
    • Gas analysis: ABG/VBG for acid-base disturbances.
    • Toxicology: Urine drug screen, ethanol, salicylate, & acetaminophen levels.
    • Infectious: Blood cultures, urinalysis, chest X-ray.
  • Tier 3: Imaging & Specialized Tests
    • Non-contrast head CT: The essential first scan for any undifferentiated AMS to rule out intracranial hemorrhage, mass, or hydrocephalus.
    • EEG: Critical if non-convulsive status epilepticus is suspected, especially with a negative CT.
    • Lumbar Puncture (LP): If meningitis/encephalitis is a concern (after CT).

⭐ Always obtain an EEG if a patient's mental status fails to improve despite a normal head CT and correction of metabolic derangements. Non-convulsive status epilepticus is a common, reversible, and often missed diagnosis.

High‑Yield Points - ⚡ Biggest Takeaways

  • The differential for AMS is broad; use mnemonics like AEIOU-TIPS to structure your approach.
  • Always check fingerstick glucose immediately; hypoglycemia is a common and reversible cause.
  • In suspected Wernicke's encephalopathy (alcoholism, malnutrition), give thiamine before administering glucose.
  • Delirium is an acute and fluctuating disturbance in attention, unlike the chronic progression of dementia.
  • Suspect opioid overdose with the triad of respiratory depression, miosis, and CNS depression.
  • Have a low threshold for lumbar puncture if infection (meningitis/encephalitis) is suspected.

Practice Questions: Altered mental status approach

Test your understanding with these related questions

A 24-year-old man presents to the emergency department after a motor vehicle collision. He was in the front seat and unrestrained driver in a head on collision. His temperature is 99.2°F (37.3°C), blood pressure is 90/65 mmHg, pulse is 152/min, respirations are 16/min, and oxygen saturation is 100% on room air. Physical exam is notable for a young man who opens his eyes spontaneously and is looking around. He answers questions with inappropriate responses but discernible words. He withdraws from pain but does not have purposeful movement. Which of the following is this patient's Glasgow coma scale?

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Flashcards: Altered mental status approach

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Do patients with point of service (POS) insurance plans require PCP referral for specialist visits?_____

TAP TO REVEAL ANSWER

Do patients with point of service (POS) insurance plans require PCP referral for specialist visits?_____

Yes

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